Document Detail

Percutaneous absorption of inorganic lead compounds.
MedLine Citation:
PMID:  12529920     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine percutaneous absorption of lead compounds, including lead sulfate, lead oxide, lead powder, and lead stearate. The lead content on the skin surface of 10 lead-battery workers was measured by the method of skin stripping, and urinary lead content of rats was measured with epicutaneous application of four lead compounds: lead sulfate, lead oxide, lead powder, and lead stearate. There were significant amounts of lead on the 9th and 10th skin strippings of the dorsal hand and the back of lead workers. The amount of lead on the dorsal hand was significantly correlated with the amount in the blood (n = 10, r 2 = 0.66, p < 0.05, linear regression). In rats, after lead compounds were applied for 12 days, total lead amount in urine significantly increased to 146.0 +/- 6.4 ng (SD) for lead stearate, 123.1 +/- 7.2 ng for lead sulfate, 115.9 +/- 5.3 ng for lead oxide, 47.8 +/- 6.9 ng for lead powder, and 10.3 ng for the control, which indicated significant skin absorption. It was concluded that significant amounts of inorganic lead compounds can be absorbed through the skin, and skin protection in lead-working or any contaminated environment should be carefully considered.
Chee-Ching Sun; Ten-Tsao Wong; Yaw-Huei Hwang; Kun-Yu Chao; Shiou-Hwa Jee; Jung-Der Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIHA journal : a journal for the science of occupational and environmental health and safety     Volume:  63     ISSN:  1542-8117     ISO Abbreviation:  AIHA J (Fairfax, Va)     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101146781     Medline TA:  AIHA J (Fairfax, Va)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  641-6     Citation Subset:  IM    
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Chemical Industry
Gloves, Protective
Lead / blood,  metabolism*,  urine
Linear Models
Occupational Exposure / adverse effects
Oxides / blood,  metabolism*,  urine
Rats, Wistar
Skin / metabolism*
Skin Absorption*
Reg. No./Substance:
0/Oxides; 1317-36-8/lead oxide; 7439-92-1/Lead; 7446-14-2/lead sulfate
Comment In:
AIHA J (Fairfax, Va). 2003 Mar-Apr;64(2):169-70; author reply 170   [PMID:  12705287 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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