| Percutaneous ablation of malignant liver tumor in rabbits using low radio frequency energy. | |
| | |
MedLine Citation:
|
PMID: 9414419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Radio frequency (RF) current has been used successfully to ablate normal human tissue. To further investigate the clinical application of this modality in tumors we studied the potential of using RF percutaneously to destroy experimental liver tumors. Thirty five outbred albino rabbits underwent liver VX2 tumor direct-implantation during open surgery. After 21 days ultrasonography was performed revealing tumor presence and size. A shielded RF needle was designed so that it could be inserted percutaneously through an introducing needle, and an electrical insulation shield covering the RF needle could be retracted to control the length of the exposed RF needle inside the tissue. Twenty two days after tumor implantation RF was applied via the aforementioned needle using a ZoMed International RF generator. In one group of rabbits the procedure was performed under direct vision during open surgery and on the other group treatment was applied percutaneously, guiding the needle by tumor palpation. Rabbits were killed 3 days later and pathology revealed 4 to 25 mm intratumoral RF induced lesions. A direct relation was found between lesion size, power and duration of RF application (At 7.5 W, r = 0.48, p = 0.032). Based on our preliminary results we may conclude that RF may have clinical application in the near future for percutaneous local tumor control in parenchymal organs. |
| | |
Authors:
|
O Nativ; B Moskovitz; E Sabo; A Shalhav; J Kaftori; Y Barbara; D Mordohovich; B Goldwasser |
Related Documents
:
|
19427559 - Mid-ventilation concept for mobile pulmonary tumors: internal tumor trajectory versus s... 7298949 - Volumetric ct analysis of hepatic tumors. 10982009 - A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tum... 20214219 - Analysis of patients with rapid aggressive tumor progression of hepatocellular carcinom... 19922319 - Synchronous parenchymal renal tumors of different histology in the same kidney. 12764649 - Open radio-frequency thermal ablation of renal vx2 tumors in a rabbit model using a coo... 22319429 - In silico experimentation of glioma microenvironment development and anti-tumor therapy. 11708809 - Antiproliferative activity of reic/dkk-3 and its significant down-regulation in non-sma... 15708859 - 2-methoxyestradiol-induced apoptosis in prostate cancer cells requires smad7. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of experimental therapeutics & oncology Volume: 1 ISSN: 1359-4117 ISO Abbreviation: J. Exp. Ther. Oncol. Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1998-01-30 Completed Date: 1998-01-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9604933 Medline TA: J Exp Ther Oncol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 312-6 Citation Subset: IM |
Affiliation:
|
Department of Urology, Bnai Zion Medical Center, Haifa, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Hyperthermia, Induced* Liver Neoplasms, Experimental / therapy*, ultrasonography Necrosis Neoplasm Transplantation Rabbits Radio Waves* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hexadecylphosphocholine inhibits phosphatidylinositol and phosphatidylcholine phospholipase C in hum...
Next Document: Ki-67 and p53 immunoreactive stain and early colorectal neoplasms.