Document Detail


Percutaneous ultrasound-guided biopsies in the evaluation of thoracic tumours after PET-CT: a prospective diagnostic study.
MedLine Citation:
PMID:  21934274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Lesions detected by positron emission tomography-computed tomography (PET-CT) during the analysis of thoracic tumours are often impalpable at physical examination, and subsequent ultrasound (US) may aid in finding these lesions for pathologic evaluation.
OBJECTIVES: The success rate of percutaneous US-guided biopsies of palpable and non-palpable lesions and the impact on tumour stage were studied prospectively.
METHODS: Lesions, significant for diagnosis and disease stage, with metabolic activity on PET-CT and presumed appropriate for percutaneous approach under US guidance were selected for cytologic aspiration or tissue core biopsies.
RESULTS: In 127 patients, 134 lesions (subdivided into 24 local thoracic, 74 supraclavicular and 36 distant metastatic lesions) were biopsied percutaneously under US guidance. Malignancy, benign disease and inadequate biopsies were found in 80% (106/134), 14% (19/134) and 7% (9/134), respectively. In 55% (56/102) of patients, biopsies confirmed the disease stage. Fifty-one percent (18/35) of distant lesions and 54% (43/68) of supraclavicular lesions were impalpable on physical examination.
CONCLUSIONS: US-guided biopsies in patients with suspected thoracic malignancy on PET-CT provide an excellent tool for obtaining a pathological diagnosis, leading to a definitive disease stage in over half of the patients.
Authors:
Jos A Stigt; Ad H Oostdijk; James E Boers; Jan Willem K van den Berg; Harry J M Groen
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-09-16
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  83     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-04-03     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy, Needle / methods*
Bronchoscopy
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multimodal Imaging*
Neoplasm Staging / methods*
Pilot Projects
Positron-Emission Tomography*
Reproducibility of Results
Thoracic Neoplasms / diagnosis*
Thorax / ultrasonography*
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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