Document Detail


Percutaneous left ventricular assist devices in ventricular tachycardia ablation: multicenter experience.
MedLine Citation:
PMID:  24532564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Data on relative safety, efficacy, and role of different percutaneous left ventricular assist devices for hemodynamic support during the ventricular tachycardia (VT) ablation procedure are limited.
METHODS AND RESULTS: We performed a multicenter, observational study from a prospective registry including all consecutive patients (N=66) undergoing VT ablation with a percutaneous left ventricular assist devices in 6 centers in the United States. Patients with intra-aortic balloon pump (IABP group; N=22) were compared with patients with either an Impella or a TandemHeart device (non-IABP group; N=44). There were no significant differences in the baseline characteristics between both the groups. In non-IABP group (1) more patients could undergo entrainment/activation mapping (82% versus 59%; P=0.046), (2) more number of unstable VTs could be mapped and ablated per patient (1.05±0.78 versus 0.32±0.48; P<0.001), (3) more number of VTs could be terminated by ablation (1.59±1.0 versus 0.91±0.81; P=0.007), and (4) fewer VTs were terminated with rescue shocks (1.9±2.2 versus 3.0±1.5; P=0.049) when compared with IABP group. Complications of the procedure trended to be more in the non-IABP group when compared with those in the IABP group (32% versus 14%; P=0.143). Intermediate term outcomes (mortality and VT recurrence) during 12±5-month follow-up were not different between both groups. Left ventricular ejection fraction ≤15% was a strong and independent predictor of in-hospital mortality (53% versus 4%; P<0.001).
CONCLUSIONS: Impella and TandemHeart use in VT ablation facilitates extensive activation mapping of several unstable VTs and requires fewer rescue shocks during the procedure when compared with using IABP.
Authors:
Yeruva Madhu Reddy; Larry Chinitz; Moussa Mansour; T Jared Bunch; Srijoy Mahapatra; Vijay Swarup; Luigi Di Biase; Sudharani Bommana; Donita Atkins; Roderick Tung; Kalyanam Shivkumar; J David Burkhardt; Jeremy Ruskin; Andrea Natale; Dhanunjaya Lakkireddy
Related Documents :
24751474 - Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with st-elevate...
24900054 - Imaging myocardial ischemia and reperfusion injury via cy5.5-annexin v.
24507674 - Effect of peroxisome proliferator-activated receptor gamma agonist on heart of rabbits ...
23801824 - Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant r...
23664294 - Impact of age on long-term outcome after primary angioplasty with bare-metal or drug-el...
24096574 - Macrophage migration inhibitory factor for the early prediction of infarct size.
Publication Detail:
Type:  Journal Article; Multicenter Study; Observational Study     Date:  2014-02-14
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  7     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-16     Completed Date:  2014-06-03     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cardiac Catheterization
Catheter Ablation / methods*
Echocardiography
Electrocardiography
Female
Follow-Up Studies
Hospital Mortality / trends
Humans
Intra-Aortic Balloon Pumping / instrumentation*
Male
Middle Aged
Prospective Studies
Tachycardia, Ventricular / mortality,  physiopathology,  therapy*
Treatment Outcome
United States / epidemiology
Ventricular Function, Left*
Grant Support
ID/Acronym/Agency:
R01 HL084261/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Circ Arrhythm Electrophysiol. 2014 Apr;7(2):192-4   [PMID:  24736421 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  miRNA regulation in the context of functional protein networks: principles and applications.
Next Document:  Overexpression of angiomotin in sinonasal inverted papilloma.