Document Detail

Percutaneous left ventricular assist devices in ventricular tachycardia ablation: multicenter experience.
MedLine Citation:
PMID:  24532564     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Data on relative safety, efficacy, and role of different percutaneous left ventricular assist devices for hemodynamic support during the ventricular tachycardia (VT) ablation procedure are limited.
METHODS AND RESULTS: We performed a multicenter, observational study from a prospective registry including all consecutive patients (N=66) undergoing VT ablation with a percutaneous left ventricular assist devices in 6 centers in the United States. Patients with intra-aortic balloon pump (IABP group; N=22) were compared with patients with either an Impella or a TandemHeart device (non-IABP group; N=44). There were no significant differences in the baseline characteristics between both the groups. In non-IABP group (1) more patients could undergo entrainment/activation mapping (82% versus 59%; P=0.046), (2) more number of unstable VTs could be mapped and ablated per patient (1.05±0.78 versus 0.32±0.48; P<0.001), (3) more number of VTs could be terminated by ablation (1.59±1.0 versus 0.91±0.81; P=0.007), and (4) fewer VTs were terminated with rescue shocks (1.9±2.2 versus 3.0±1.5; P=0.049) when compared with IABP group. Complications of the procedure trended to be more in the non-IABP group when compared with those in the IABP group (32% versus 14%; P=0.143). Intermediate term outcomes (mortality and VT recurrence) during 12±5-month follow-up were not different between both groups. Left ventricular ejection fraction ≤15% was a strong and independent predictor of in-hospital mortality (53% versus 4%; P<0.001).
CONCLUSIONS: Impella and TandemHeart use in VT ablation facilitates extensive activation mapping of several unstable VTs and requires fewer rescue shocks during the procedure when compared with using IABP.
Yeruva Madhu Reddy; Larry Chinitz; Moussa Mansour; T Jared Bunch; Srijoy Mahapatra; Vijay Swarup; Luigi Di Biase; Sudharani Bommana; Donita Atkins; Roderick Tung; Kalyanam Shivkumar; J David Burkhardt; Jeremy Ruskin; Andrea Natale; Dhanunjaya Lakkireddy
Related Documents :
24751474 - Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with st-elevate...
24900054 - Imaging myocardial ischemia and reperfusion injury via cy5.5-annexin v.
24507674 - Effect of peroxisome proliferator-activated receptor gamma agonist on heart of rabbits ...
23801824 - Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant r...
23664294 - Impact of age on long-term outcome after primary angioplasty with bare-metal or drug-el...
24096574 - Macrophage migration inhibitory factor for the early prediction of infarct size.
Publication Detail:
Type:  Journal Article; Multicenter Study; Observational Study     Date:  2014-02-14
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  7     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-16     Completed Date:  2014-06-03     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Catheterization
Catheter Ablation / methods*
Follow-Up Studies
Hospital Mortality / trends
Intra-Aortic Balloon Pumping / instrumentation*
Middle Aged
Prospective Studies
Tachycardia, Ventricular / mortality,  physiopathology,  therapy*
Treatment Outcome
United States / epidemiology
Ventricular Function, Left*
Grant Support
Comment In:
Circ Arrhythm Electrophysiol. 2014 Apr;7(2):192-4   [PMID:  24736421 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  miRNA regulation in the context of functional protein networks: principles and applications.
Next Document:  Overexpression of angiomotin in sinonasal inverted papilloma.