| Perceptual wind-up in the human oesophagus is enhanced by central sensitisation. | |
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MedLine Citation:
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PMID: 16492716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oesophageal acid infusion induces enhanced pain hypersensitivity in non-acid exposed upper oesophagus (secondary hyperalgesia) in patients with non-cardiac chest pain, thus suggesting central sensitisation contributes to visceral pain hypersensitivity in functional gut disorders (FGD). Perceptual wind-up (increased pain perception to constant intensity sensory stimuli at frequencies>or=0.3 Hz) is used as a proxy for central sensitisation to investigate pain syndromes where pain hypersensitivity is important (for example, fibromyalgia). AIMS: Wind-up in central sensitisation induced human visceral pain hypersensitivity has not been explored. We hypothesised that if wind-up is a proxy for central sensitisation induced human visceral pain hypersensitivity, then oesophageal wind-up should be enhanced by secondary hyperalgesia. METHODS: In eight healthy volunteers (seven males; mean age 32 years), perception at pain threshold to a train of 20 electrical stimuli applied to the hand and upper oesophagus (UO) at either 0.1 Hz (control) or 2 Hz was determined before and one hour after a 30 minute lower oesophageal acid infusion. RESULTS: Wind-up occurred only with the 2 Hz train in the UO and hand (both p=0.01). Following acid infusion, pain threshold decreased (17 (4)%; p=0.01) in the UO, suggesting the presence of secondary hyperalgesia. Wind-up to the 2 Hz train increased in the UO (wind-up ratio 1.4 (0.1) to 1.6 (0.1); p=0.03) but not in the hand (wind-up ratio 1.3 (0.1) and 1.3 (0.1); p=0.3) CONCLUSION: Enhanced wind-up after secondary oesophageal hyperalgesia suggests that visceral pain hypersensitivity induced by central sensitisation results from increased central neuronal excitability. Wind-up may offer new opportunities to investigate the contribution of central neuronal changes to symptoms in FGD. |
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Authors:
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S Sarkar; C J Woolf; A R Hobson; D G Thompson; Q Aziz |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-02-21 |
Journal Detail:
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Title: Gut Volume: 55 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-12 Completed Date: 2006-07-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 920-5 Citation Subset: AIM; IM |
Affiliation:
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Department of GI Science, Clinical Sciences Building, Hope Hospital, Salford, University of Manchester, M6 8HD, UK. sanchoy@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Electric Stimulation Esophagus / physiology* Hand Humans Hydrochloric Acid / pharmacology Hydrogen-Ion Concentration Learning / physiology* Male Middle Aged Pain Measurement Pain Threshold / physiology* Perceptual Distortion |
| Chemical | |
Reg. No./Substance:
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7647-01-0/Hydrochloric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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