Document Detail

Perceptual and physiologic effects of histamine challenge on nasal breathing.
MedLine Citation:
PMID:  10711325     Owner:  NLM     Status:  MEDLINE    
The purpose of this study is to determine the effect of histamine-induced nasal congestion on nasal airflow and the perception of externally applied resistance to nasal breathing. Nasal cross-sectional area and nasal airflow during free breathing were measured in 15 adult subjects before and after histamine challenge. The threshold for perception of resistance to nasal breathing was determined using a dynamic perturbator device, with both free breathing and controlled nasal air-flow. The average threshold for perception of nasal resistance was 0.383 Pa/cm3/s at baseline. After histamine application, there was a significant decrease in nasal cross-sectional area (p = 0.0001), associated with a decrease in nasal airflow (r = 0.6). The average threshold of perception increased to 1.373 Pa/cm3/s (p < 0.0001). When nasal airflow was controlled at the baseline rate, the threshold of perception improved to 0.638 Pa/cm3/s (p = 0.024). These findings indicate that nasal congestion causes a reduction in both nasal airflow and the perception of resistance to nasal breathing. The ability to detect nasal airway impairment is improved with increased nasal airflow. An improved understanding of the physiology of the subjective perception of nasal patency may lead to innovative methods for the treatment of nasal obstruction.
A P Lane; A F Drake; D W Warren
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of rhinology     Volume:  14     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill 27599-7600, USA.
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MeSH Terms
Airway Resistance / drug effects*
Breath Tests
Equipment Design
Histamine / diagnostic use,  pharmacology*
Nasal Mucosa / drug effects
Nasal Obstruction / chemically induced,  physiopathology*
Nose / anatomy & histology,  physiology
Respiration / drug effects*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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