Document Detail

Perception of changes in wall tension of the proximal stomach in humans.
MedLine Citation:
PMID:  11454795     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hypersensitivity to distension of the stomach is a frequent finding in functional dyspepsia. During gastric distension studies both wall tension and elongation are increased. AIM: We wished to distinguish changes in wall tension from changes in elongation in the genesis of perception of mechanical stimuli originating from the proximal stomach in healthy subjects. SUBJECTS AND METHODS: Twenty six volunteers were studied using gastric barostat and antroduodenal manometry. In 14 subjects, stepwise isobaric and isovolumetric distensions were performed before and during erythromycin infusion. In all volunteers, on a separate occasion, phasic contractions of the proximal stomach were detected as intraballoon pressure increases during fixed volume inflation. These contractions were matched with perception changes during two 10 minute periods, before and during administration of erythromycin. RESULTS: Erythromycin significantly lowered the perception and discomfort thresholds during stepwise gastric distension. During fixed volume inflation, erythromycin increased the number and amplitude of fundic contractions and enhanced their perception from 51.1 (7.4)% to 64.0 (4.7)%. The proportion of perception score increases coinciding with fundic contractions increased from 47.3 (0.7)% to 81.5 (0.5)%. The amplitude of correctly identified isolated fundic pressure waves was higher compared with non-identified waves. CONCLUSIONS: These results support the hypothesis that changes in gastric wall tension may be involved in the genesis of symptoms originating from the stomach.
H Piessevaux; J Tack; A Wilmer; B Coulie; A Geubel; J Janssens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  49     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-08-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  AIM; IM    
Department of Internal Medicine, Division of Gastroenterology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Analysis of Variance
Area Under Curve
Erythromycin / administration & dosage
Gastrointestinal Agents / administration & dosage
Mechanoreceptors / drug effects,  physiology*
Pain Threshold / drug effects,  physiology
Perception / drug effects,  physiology*
Stomach / drug effects,  physiology*
Stress, Physiological / drug therapy,  physiopathology*
Reg. No./Substance:
0/Gastrointestinal Agents; 114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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