| Perception of changes in wall tension of the proximal stomach in humans. | |
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MedLine Citation:
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PMID: 11454795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypersensitivity to distension of the stomach is a frequent finding in functional dyspepsia. During gastric distension studies both wall tension and elongation are increased. AIM: We wished to distinguish changes in wall tension from changes in elongation in the genesis of perception of mechanical stimuli originating from the proximal stomach in healthy subjects. SUBJECTS AND METHODS: Twenty six volunteers were studied using gastric barostat and antroduodenal manometry. In 14 subjects, stepwise isobaric and isovolumetric distensions were performed before and during erythromycin infusion. In all volunteers, on a separate occasion, phasic contractions of the proximal stomach were detected as intraballoon pressure increases during fixed volume inflation. These contractions were matched with perception changes during two 10 minute periods, before and during administration of erythromycin. RESULTS: Erythromycin significantly lowered the perception and discomfort thresholds during stepwise gastric distension. During fixed volume inflation, erythromycin increased the number and amplitude of fundic contractions and enhanced their perception from 51.1 (7.4)% to 64.0 (4.7)%. The proportion of perception score increases coinciding with fundic contractions increased from 47.3 (0.7)% to 81.5 (0.5)%. The amplitude of correctly identified isolated fundic pressure waves was higher compared with non-identified waves. CONCLUSIONS: These results support the hypothesis that changes in gastric wall tension may be involved in the genesis of symptoms originating from the stomach. |
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Authors:
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H Piessevaux; J Tack; A Wilmer; B Coulie; A Geubel; J Janssens |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 49 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-08-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Division of Gastroenterology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. piessevaux@gaen.ucl.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Area Under Curve Erythromycin / administration & dosage Female Gastrointestinal Agents / administration & dosage Humans Male Manometry Mechanoreceptors / drug effects, physiology* Pain Threshold / drug effects, physiology Perception / drug effects, physiology* Stomach / drug effects, physiology* Stress, Physiological / drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 114-07-8/Erythromycin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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