Document Detail


Percentage of tumor in prostatectomy specimens: a study of American Veterans.
MedLine Citation:
PMID:  19095570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, I have estimated the percentage of tumor by visual estimate in 447 prostatectomy specimens from American Veterans Affairs patients and related this measurement to overall survival. Although percentage of tumor was significantly related to the serum prostate-specific antigen level, tumor stage, and Gleason score-that is, it was not statistically independent from these-it was more closely associated with overall survival than any of them. Altogether, 2 variables available at the time of the prostatectomy related to survival: patient age (P = .0032; Cox proportional hazards model analysis) and percentage of tumor (P = .0013; Cox model). Patient age undoubtedly reflects the combination of comorbidities and general expected length of life. Percentage of tumor, by contrast, seems to efficiently reflect any undue hazard for early death due to prostate cancer. The results suggest that percentage of tumor is a useful prognostic variable for understanding risk of early death after prostatectomy.
Authors:
Robin T Vollmer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  131     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  AIM; IM    
Affiliation:
Laboratory Medicine, Veterans Affairs and Duke University Medical Centers, Durham, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Humans
Kaplan-Meiers Estimate
Male
Middle Aged
Prostate / pathology
Prostate-Specific Antigen / blood
Prostatectomy*
Prostatic Neoplasms / pathology*
United States
Veterans
Chemical
Reg. No./Substance:
EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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