| Percentage of Gleason pattern 4 and 5 predicts survival after radical prostatectomy. | |
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MedLine Citation:
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PMID: 17823907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Morphologic and clinical heterogeneity within tumor grades is well recognized in prostate cancer. The objective of the current study was to determine whether the combined percentage of Gleason patterns 4 and 5 in radical prostatectomy specimens is an independent predictor of cancer-specific survival in prostate cancer patients. METHODS: The radical prostatectomy specimens were analyzed from 504 consecutive prostate cancer patients who were treated at Indiana University Medical Center between 1990 and 1998. Various clinical and pathologic characteristics were analyzed. RESULTS: A higher combined percentage of Gleason patterns 4 and 5 was associated with older age, higher preoperative serum prostate-specific antigen level, higher pathologic stage, positive surgical margins, extraprostatic extension of tumor, higher Gleason score, perineural invasion, and lymph node metastasis. In the multivariate Cox regression model, the combined percentage of Gleason patterns 4 and 5 was found to be an independent predictor of cancer-specific survival (P = .04). CONCLUSIONS: The combined percentage of Gleason patterns 4 and 5 is a powerful predictor of prostate cancer-specific survival. Assessment of high-grade cancer amounts may allow for better stratification of patients into appropriate prognostic groups and treatment protocols. |
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Authors:
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Liang Cheng; Darrell D Davidson; Haiqun Lin; Michael O Koch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 110 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1967-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. liang_cheng@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology*,
surgery* Adult Age Factors Aged Aged, 80 and over Humans Kaplan-Meiers Estimate Male Middle Aged Prognosis Prostatectomy* Prostatic Neoplasms / mortality, pathology*, surgery* Retrospective Studies Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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