| Perceiving the epigenetic landscape through histone readers. | |
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MedLine Citation:
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PMID: 23211769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for regulating chromatin structure and dynamics. PTMs can alter direct interactions between histones and DNA and serve as docking sites for protein effectors, or readers, of these PTMs. Binding of the readers recruits or stabilizes various components of the nuclear signaling machinery at specific genomic sites, mediating fundamental DNA-templated processes, including gene transcription and DNA recombination, replication and repair. In this review, we highlight the latest advances in characterizing histone-binding mechanisms and identifying new epigenetic readers and summarize the functional significance of PTM recognition. |
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Authors:
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Catherine A Musselman; Marie-Eve Lalonde; Jacques Côté; Tatiana G Kutateladze |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature structural & molecular biology Volume: 19 ISSN: 1545-9985 ISO Abbreviation: Nat. Struct. Mol. Biol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-05 Completed Date: 2013-02-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101186374 Medline TA: Nat Struct Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1218-27 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation DNA / chemistry, genetics DNA Methylation DNA Repair DNA Replication Epigenesis, Genetic* Histones / chemistry* Models, Molecular Phosphorylation Recombination, Genetic Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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CA113472/CA/NCI NIH HHS; F32 HL096399/HL/NHLBI NIH HHS; GM096863/GM/NIGMS NIH HHS; MOP-14308//Canadian Institutes of Health Research; MOP-64289//Canadian Institutes of Health Research; R01 CA113472/CA/NCI NIH HHS; R01 GM096863/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histones; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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