Document Detail

Per-operative antibiotic/steroid prophylaxis of tympanostomy tube otorrhoea: chemical or mechanical effect?
MedLine Citation:
PMID:  8763370     Owner:  NLM     Status:  MEDLINE    
The per-operative instillation of ototopical antibiotic/steroid drops reduces the incidence of early otorrhoea after tympanostomy tube insertion. Whether this is due to the chemical properties of the antibiotic/steroid or simply the mechanical instillation of fluid is unclear. In this paired matched study of 161 subjects Gentisone HC was shown to significantly reduce the otorrhoea rate compared to normal saline (1.24 per cent compared with 9.32 per cent, p < 0.005, difference 8.07 per cent, 95 per cent confidence interval for difference 3.21 per cent to 12.93 per cent). Capillary viscosimetry proved Gentisone HC to be more viscous than normal saline. The benefits are due to Gentisone HC's chemical properties, and Gentisone HC rather than normal saline instillation per-operatively is recommended when tympanostomy tubes are inserted.
C A Shinkwin; G E Murty; R Simo; N S Jones
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  110     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-15     Completed Date:  1996-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  531-3     Citation Subset:  AIM; IM    
Department of Otolaryngology, University Hospital, Nottingham, UK.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*,  chemistry,  therapeutic use
Gentamicins / administration & dosage*,  chemistry,  therapeutic use
Instillation, Drug
Middle Ear Ventilation*
Otitis Media with Effusion / prevention & control*,  surgery
Postoperative Period
Saline Solution, Hypertonic / administration & dosage,  chemistry,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 0/Saline Solution, Hypertonic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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