Document Detail


Peptidoglycolipid nature of the superficial cell wall sheath of smooth-colony-forming mycobacteria.
MedLine Citation:
PMID:  7430072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most superficial cell wall layer present in smooth-colony-forming mycobacteria was isolated from serovar 20 of the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum (MAIS) serocomplex and examined chemically and by electron microscopy. Most (70 to 80%) of the fibrillar material consisted of an array of serologically active, acetylated C-myosidic peptidoglycoplipids with the basic structure (formula, see text) but in which the location of acetyl groups and the arrangement of monosaccharides have not been defined. Apparently, all serovars within the MAIS complex are characterized by structurally related superficies in which the monoglycosyl-lipopeptide portion is invariable but the oligosaccharide attachment is peculiar to each serovar. These unique inert structures may be an important factor in shielding the pathogen within phagolysosomes from lysosomal enzymes.
Authors:
W W Barrow; B P Ullom; P J Brennan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  144     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  814-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Bacterial
Cell Wall / analysis
Chemical Phenomena
Chemistry
Glycolipids / analysis*,  immunology
Glycopeptides / analysis*,  immunology
Microscopy, Electron
Mycobacterium / analysis,  immunology,  ultrastructure*
Grant Support
ID/Acronym/Agency:
AI-02079/AI/NIAID NIH HHS; AI-14687/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Glycolipids; 0/Glycopeptides; 0/peptidoglycolipids
Comments/Corrections

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