Document Detail


Peptides shorter than a minimal CTL epitope may have a higher binding affinity than the epitope for the class I Kk molecule.
MedLine Citation:
PMID:  7687804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A previously published Kk-specific motif was used to predict that an optimal Kk-restricted epitope within the nucleoprotein (NP) of influenza A/PR/8/34 virus corresponds to sequence SDYEGRLI (residues 50-57). Although this is the minimal epitope recognized by murine cytotoxic T lymphocytes (CTL), its binding affinity for the Kk molecule is increased following removal of either the N-terminal amino acid residue (S) or the N-terminal dipeptide (SD). A possible explanation for this unexpected result is that interactions between the C-terminus of the epitope and the Kk molecule contribute to the binding energy to a much greater extent than interactions between the N-terminus of the epitope and the Kk molecule.
Authors:
J Cossins; K Gould; G G Brownlee
Related Documents :
11278524 - Determination of the functional epitopes of human interleukin-18-binding protein by sit...
24058514 - Pet reveals inflammation around calcified taenia solium granulomas with perilesional ed...
2431044 - Monoclonal anti-dna igm kappa in neuropathy binds to myelin and to a conformational epi...
10357214 - Fine mapping of the binding sites of monoclonal antibodies raised against the pk tag.
16368534 - Regulation of protein 4.1r interactions with membrane proteins by ca2+ and calmodulin.
11985614 - Chimeric receptor analyses of the interactions of the ectodomains of erbb-1 with epider...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virology     Volume:  195     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-08-20     Completed Date:  1993-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  851-4     Citation Subset:  IM    
Affiliation:
Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cell Line
Epitopes*
H-2 Antigens / immunology*
Influenza A virus / immunology*
Mice
Molecular Sequence Data
Peptides / chemical synthesis,  immunology
T-Lymphocytes, Cytotoxic / immunology*
Chemical
Reg. No./Substance:
0/Epitopes; 0/H-2 Antigens; 0/H-2K(K) antigen; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification...
Next Document:  Identification and localization of a serotypic neutralization determinant on the VP2 protein of blue...