| Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain. | |
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MedLine Citation:
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PMID: 2865704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of dipeptides and an amide chemically derived from kainic acid (KA) on the response of rat striatal slices to excitatory amino acids were studied. Some of the gamma-peptides of KA were found to antagonize the response to N-methyl-D-aspartate (NMDA) more than that to quisqualate and glutamate and not to have any effect on the response to kainate. The least potent antagonists among the tested compounds were the gamma-amide of KA and the peptides of KA with beta-alanine and gamma-aminobutyric acid, whereas the gamma-kainyl peptides of the alpha-amino acids glycine, tyrosine, glutamate and KA were more active. The latter are the best blockers of the response to NMDA among the tested compounds. |
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Authors:
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O Goldberg; V I Teichberg |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 60 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-12-18 Completed Date: 1985-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartic Acid / analogs & derivatives*, antagonists & inhibitors Corpus Striatum / drug effects* Glutamates / antagonists & inhibitors Glutamic Acid Kainic Acid / analogs & derivatives*, antagonists & inhibitors Male N-Methylaspartate Oxadiazoles / antagonists & inhibitors Quisqualic Acid Rats |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Oxadiazoles; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 6384-92-5/N-Methylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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