Document Detail

Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain.
MedLine Citation:
PMID:  2865704     Owner:  NLM     Status:  MEDLINE    
The effects of dipeptides and an amide chemically derived from kainic acid (KA) on the response of rat striatal slices to excitatory amino acids were studied. Some of the gamma-peptides of KA were found to antagonize the response to N-methyl-D-aspartate (NMDA) more than that to quisqualate and glutamate and not to have any effect on the response to kainate. The least potent antagonists among the tested compounds were the gamma-amide of KA and the peptides of KA with beta-alanine and gamma-aminobutyric acid, whereas the gamma-kainyl peptides of the alpha-amino acids glycine, tyrosine, glutamate and KA were more active. The latter are the best blockers of the response to NMDA among the tested compounds.
O Goldberg; V I Teichberg
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  60     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
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MeSH Terms
Aspartic Acid / analogs & derivatives*,  antagonists & inhibitors
Corpus Striatum / drug effects*
Glutamates / antagonists & inhibitors
Glutamic Acid
Kainic Acid / analogs & derivatives*,  antagonists & inhibitors
Oxadiazoles / antagonists & inhibitors
Quisqualic Acid
Reg. No./Substance:
0/Glutamates; 0/Oxadiazoles; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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