Document Detail

Peptides containing the cell-attachment recognition signal Arg-Gly-Asp prevent gastrulation in Drosophila embryos.
MedLine Citation:
PMID:  3100959     Owner:  NLM     Status:  MEDLINE    
It has recently been suggested that the Arg-Gly-Asp sequence (RGD) forms part of a widespread cell-extracellular matrix recognition system. Analysis of the cell binding sites of vertebrate fibronectin and other extracellular proteins that interact with cell surfaces implicate the same amino acid triplet. Peptides containing this sequence inhibit certain developmental events such as cell-matrix adhesion or cellular migration in vitro and in vivo. The RGD-sequence is also part of the cellular recognition site of the aggregation protein discoidin I in Dictyostelium suggesting that the RGD-recognition system could be universally used. In Drosophila, despite its advanced genetics, very little is known about the extracellular components that are involved in cell movements and morphogenesis. We report here that peptides containing the RGD-sequence prevent gastrulation of Drosophila embryos. The phenotypic effect is similar to that observed in the dorsal-group mutants: no ventral furrow is formed and the embryos lack dorsal-ventral polarity. The specificity of the inhibiting action suggests that the RGD-sequence may also be used by invertebrates to mediate cell-attachment phenomena.
C Naidet; M Sémériva; K M Yamada; J P Thiery
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  325     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:    1987 Jan 22-28
Date Detail:
Created Date:  1987-02-26     Completed Date:  1987-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  348-50     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Cell Adhesion
Drosophila melanogaster / embryology*,  genetics
Gastrula / cytology*
Morphogenesis / drug effects*
Oligopeptides / pharmacology
Reg. No./Substance:

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