Document Detail


Peptidergic transmission in the brain. V. Systemic correlates of central activation.
MedLine Citation:
PMID:  1656399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhibition of the hippocampus by the medial amygdala is mediated by vasopressin-like peptide. Because vasopressin has action on the periphery as well as the brain, we conducted experiments to evaluate the relationship between possible peripheral actions and the central effects of the endogenous peptide. In the acutely anesthetized rat, peptide-mediated inhibition of the hippocampus is not associated with significant changes in heart rate, blood pressure or body temperature. Peripheral injections of peptide agonist fail to evoke the central inhibition, and peripheral injections of peptide antagonist fail to block the central inhibition. Stimulation of central nuclei that contain vasopressin or a similar peptide also fail to duplicate the effect of stimulating the amygdala. We conclude that the peptidergic transmission is independent of peripheral causes or correlates.
Authors:
K Raese; D Albeck; R Cooper; S Arnold; C Le; B Bradley; T Smock
Related Documents :
22333139 - Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating s...
16443679 - Intracellular targeting of truncated secretory peptides in the mammalian heart and brain.
7722509 - A novel cdna sequence encoding the precursor of the d-amino acid-containing neuropeptid...
22828809 - Antimicrobial peptide diversity in the skin of the torrent frog, amolops jingdongensis.
22284819 - Peptide-cleaving agents for human islet amyloid polypeptide containing substrate recogn...
19968759 - Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neurop...
8990499 - Stability and folding of the sh3 domain of bruton's tyrosine kinase.
15805109 - Structure and mode of action of the membrane-permeabilizing antimicrobial peptide phero...
18547979 - Identification of peptides that inhibit regulator of g protein signaling 4 function.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Colorado, Boulder 80309.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amygdala / drug effects,  physiology
Animals
Blood Pressure / drug effects,  physiology
Body Temperature / drug effects,  physiology
Brain / drug effects,  physiology*
Electric Stimulation
Heart Rate / drug effects,  physiology
Hippocampus / drug effects,  physiology
Male
Paraventricular Hypothalamic Nucleus / drug effects,  physiology
Rats
Rats, Inbred Strains
Synaptic Transmission / drug effects,  physiology*
Vasopressins / pharmacology,  physiology*
Grant Support
ID/Acronym/Agency:
MH 456202/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Peptidergic transmission in the brain. VI. Behavioral consequences of central activation.
Next Document:  Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultur...