Document Detail

Peptidergic transmission in the brain. V. Systemic correlates of central activation.
MedLine Citation:
PMID:  1656399     Owner:  NLM     Status:  MEDLINE    
Inhibition of the hippocampus by the medial amygdala is mediated by vasopressin-like peptide. Because vasopressin has action on the periphery as well as the brain, we conducted experiments to evaluate the relationship between possible peripheral actions and the central effects of the endogenous peptide. In the acutely anesthetized rat, peptide-mediated inhibition of the hippocampus is not associated with significant changes in heart rate, blood pressure or body temperature. Peripheral injections of peptide agonist fail to evoke the central inhibition, and peripheral injections of peptide antagonist fail to block the central inhibition. Stimulation of central nuclei that contain vasopressin or a similar peptide also fail to duplicate the effect of stimulating the amygdala. We conclude that the peptidergic transmission is independent of peripheral causes or correlates.
K Raese; D Albeck; R Cooper; S Arnold; C Le; B Bradley; T Smock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  IM    
Department of Psychology, University of Colorado, Boulder 80309.
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MeSH Terms
Amygdala / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Body Temperature / drug effects,  physiology
Brain / drug effects,  physiology*
Electric Stimulation
Heart Rate / drug effects,  physiology
Hippocampus / drug effects,  physiology
Paraventricular Hypothalamic Nucleus / drug effects,  physiology
Rats, Inbred Strains
Synaptic Transmission / drug effects,  physiology*
Vasopressins / pharmacology,  physiology*
Grant Support
Reg. No./Substance:

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