| Peptidergic transmission in the brain. V. Systemic correlates of central activation. | |
| | |
MedLine Citation:
|
PMID: 1656399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Inhibition of the hippocampus by the medial amygdala is mediated by vasopressin-like peptide. Because vasopressin has action on the periphery as well as the brain, we conducted experiments to evaluate the relationship between possible peripheral actions and the central effects of the endogenous peptide. In the acutely anesthetized rat, peptide-mediated inhibition of the hippocampus is not associated with significant changes in heart rate, blood pressure or body temperature. Peripheral injections of peptide agonist fail to evoke the central inhibition, and peripheral injections of peptide antagonist fail to block the central inhibition. Stimulation of central nuclei that contain vasopressin or a similar peptide also fail to duplicate the effect of stimulating the amygdala. We conclude that the peptidergic transmission is independent of peripheral causes or correlates. |
| | |
Authors:
|
K Raese; D Albeck; R Cooper; S Arnold; C Le; B Bradley; T Smock |
Related Documents
:
|
22333139 - Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating s... 16443679 - Intracellular targeting of truncated secretory peptides in the mammalian heart and brain. 7722509 - A novel cdna sequence encoding the precursor of the d-amino acid-containing neuropeptid... 22828809 - Antimicrobial peptide diversity in the skin of the torrent frog, amolops jingdongensis. 22284819 - Peptide-cleaving agents for human islet amyloid polypeptide containing substrate recogn... 19968759 - Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neurop... 8990499 - Stability and folding of the sh3 domain of bruton's tyrosine kinase. 15805109 - Structure and mode of action of the membrane-permeabilizing antimicrobial peptide phero... 18547979 - Identification of peptides that inhibit regulator of g protein signaling 4 function. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Peptides Volume: 12 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1991 May-Jun |
Date Detail:
|
Created Date: 1991-10-31 Completed Date: 1991-10-31 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 461-4 Citation Subset: IM |
Affiliation:
|
Department of Psychology, University of Colorado, Boulder 80309. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
drug effects,
physiology Animals Blood Pressure / drug effects, physiology Body Temperature / drug effects, physiology Brain / drug effects, physiology* Electric Stimulation Heart Rate / drug effects, physiology Hippocampus / drug effects, physiology Male Paraventricular Hypothalamic Nucleus / drug effects, physiology Rats Rats, Inbred Strains Synaptic Transmission / drug effects, physiology* Vasopressins / pharmacology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
MH 456202/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
11000-17-2/Vasopressins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peptidergic transmission in the brain. VI. Behavioral consequences of central activation.
Next Document: Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultur...