Document Detail


Peptide transport and animal growth: the fish paradigm.
MedLine Citation:
PMID:  21389019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein digestion products are transported from the intestinal lumen into the enterocyte both in the form of free amino acids (AAs), by a large variety of brush border membrane AA transporters, and in the form of di/tripeptides, by a single brush border membrane transporter known as PEPtide Transporter 1 (PEPT1). Recent data indicate that, at least in teleost fish, PEPT1 plays a significant role in animal growth by operating, at the gastrointestinal level, as part of an integrated response network to food availability that directly supports body weight. Notably, PEPT1 responds to both fasting and refeeding and is involved in a phenomenon known as compensatory growth (a phase of accelerated growth when food levels are restored after a period of growth depression). In particular, PEPT1 expression decreases during fasting and increases during refeeding, which is the opposite of what observed so far in mammals and birds. These findings in teleost fish document, to our knowledge, for the first time in a vertebrate model, a direct correlation between the expression of an intestinal transporter, such as PEPT1, primarily involved in the uptake of dietary protein degradation products and animal growth.
Authors:
Tiziano Verri; Genciana Terova; Konrad Dabrowski; Marco Saroglia
Related Documents :
21535539 - Quantitative evaluation of microstructural changes and their relations with some physic...
24132079 - Fish gut microbiota analysis differentiates physiology and behavior of invasive asian c...
21392559 - Maternal exposure to benzo[b]fluoranthene disturbs reproductive performance in male off...
24385059 - Spices as a source of lead exposure: a market-basket survey in sri lanka.
21251189 - Biology of the sauropod dinosaurs: the evolution of gigantism.
23409399 - Shigellosis outbreak at addis ababa university: march-april 2010.
21549059 - Investigations on the frequency of norovirus contamination of ready-to-eat food items i...
21719989 - Application of the new logistic model to microbial growth prediction in food.
8073049 - Role of gonadal steroids and inhibitory photoperiod in regulating body weight and food ...
Publication Detail:
Type:  Journal Article     Date:  2011-03-09
Journal Detail:
Title:  Biology letters     Volume:  7     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-11-21     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Copyright Information:
This journal is © 2011 The Royal Society
Affiliation:
Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy. tiziano.verri@unisalento.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Fishes / growth & development*
Peptides / metabolism*
Symporters / physiology*
Chemical
Reg. No./Substance:
0/PepT1 protein; 0/Peptides; 0/Symporters
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Critically endangered blonde capuchins fish for termites and use new techniques to accomplish the ta...
Next Document:  Nuclear magnetic resonance analysis of protein-DNA interactions.