| Peptide nucleic acid (PNA): a model structure for the primordial genetic material? | |
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MedLine Citation:
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PMID: 8115163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA monomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication. |
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Authors:
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P E Nielsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life Volume: 23 ISSN: 0169-6149 ISO Abbreviation: Orig Life Evol Biosph Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-28 Completed Date: 1994-03-28 Revised Date: 2001-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8610391 Medline TA: Orig Life Evol Biosph Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 323-7 Citation Subset: IM; S |
Affiliation:
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Department of Biochemistry B, Panum Institute, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Biogenesis* DNA / chemistry, genetics Models, Chemical Models, Genetic* Molecular Conformation Molecular Sequence Data Molecular Structure Nucleic Acids / chemistry, genetics* Peptides / chemistry, genetics* RNA, Catalytic / chemistry, genetics |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Peptides; 0/RNA, Catalytic; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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