Document Detail


Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques.
MedLine Citation:
PMID:  16249445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide YY(3-36) [PYY(3-36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3-36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3-36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3-36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3-36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY(3-36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3-36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.
Authors:
Frank H Koegler; Pablo J Enriori; Sonja K Billes; Diana L Takahashi; Meghan S Martin; Randall L Clark; Anne E Evans; Kevin L Grove; Judy L Cameron; Michael A Cowley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Diabetes     Volume:  54     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2006-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3198-204     Citation Subset:  AIM; IM    
Affiliation:
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Administration Schedule
Feeding Behavior / drug effects*,  physiology
Glucose Tolerance Test
Macaca mulatta / metabolism*
Male
Peptide YY / administration & dosage,  pharmacology*
Time Factors
Weight Loss / drug effects*
Grant Support
ID/Acronym/Agency:
5 P51-RR-00163/RR/NCRR NIH HHS; DK-060685/DK/NIDDK NIH HHS; DK-55819/DK/NIDDK NIH HHS; DK-622-2/DK/NIDDK NIH HHS; TW/HD-00668/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36)

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