Document Detail

Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty.
MedLine Citation:
PMID:  12082881     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Peptide YY (PYY) secretion pattern was assessed in morbidly obese (MO) patients before and after vertical banded gastroplasty (VBG). METHODS: 12 MO patients (10 women, 2 men) age 29-62 years, BMI 50.7 +/- 9.6 kg/m2, treated with a VBG were studied. Before surgery, blood samples were taken in basal conditions of fasting and 10, 15, 20, 30 and 60 min after the ingestion of a semiliquid test meal. This was repeated in the same patients 6 and 12 months after VBG. Blood samples were also taken from 6 healthy non-obese subjects as controls. PYY plasma concentration was measured by radioimmunoassay with I125. RESULTS: There were statistically significant differences between the preoperative PYY concentration in MO patients compared to controls. After a VBG, PYY concentration varied significantly compared to the preoperative levels. There was no significant difference between the PYY concentrations in the MO patients after VBG and the controls. CONCLUSION: PYY concentration is lower in MO patients compared with non-obese. After VBG, PYY concentration gradually rises to the control levels.
Mercedes Alvarez Bartolomé; María Borque; Javier Martinez-Sarmiento; Eugenio Aparicio; Carmen Hernández; Lucio Cabrerizo; J A Fernández-Represa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity surgery     Volume:  12     ISSN:  0960-8923     ISO Abbreviation:  Obes Surg     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-26     Completed Date:  2002-12-13     Revised Date:  2007-12-05    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  324-7     Citation Subset:  IM    
Department of Surgery, Hospital Clínico San Carlos, C/Martín Lagos s/n, 28040 Madrid, Spain.
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MeSH Terms
Body Mass Index
Middle Aged
Obesity, Morbid / blood*,  physiopathology,  surgery*
Peptide YY / blood*,  secretion*
Postoperative Period
Time Factors
Weight Loss / physiology
Reg. No./Substance:
106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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