Document Detail

Peptic ulcer and non-steroidal anti-inflammatory agents.
MedLine Citation:
PMID:  3732900     Owner:  NLM     Status:  MEDLINE    
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.
J M Duggan; A J Dobson; H Johnson; P Fahey
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  27     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  929-33     Citation Subset:  AIM; IM    
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MeSH Terms
Acetaminophen / adverse effects
Anti-Inflammatory Agents / adverse effects*
Aspirin / adverse effects
Duodenal Ulcer / chemically induced
Middle Aged
Peptic Ulcer / chemically induced*
Social Class
Stomach Ulcer / chemically induced
Reg. No./Substance:
0/Anti-Inflammatory Agents; 103-90-2/Acetaminophen; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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