Document Detail


Peptic ulcer in the elderly--a double-blind, short-term study comparing nizatidine 300 mg with ranitidine 300 mg. GISU (Interdisciplinary Ulcer Study Group).
MedLine Citation:
PMID:  8161671     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STATISTICS: chi-squared test, Fisher's exact test, Student t-test for unpaired data. The study included 170 duodenal ulcer and 75 gastric ulcer patients. Of these, 83/170 duodenal ulcer and 38/75 gastric ulcer patients were treated with nizatidine 300 mg and the remainder with ranitidine 300 mg. The groups were well-matched for common clinical data. Eight patients dropped out. Healing rates at 6 and 12 weeks were 81.9% and 91.5% for nizatidine-treated duodenal ulcer patients versus 78.1% and 94.2% for ranitidine-treated duodenal ulcer cases (P: N.S.); 6 and 12-week healing rates were 76.3% and 89.5% for nizatidine-treated gastric ulcer patients versus 67.6% and 83.8% for ranitidine-treated gastric ulcer patients (P: N.S.). No slow healing risk factors were found. Only minor adverse events were registered.
IN CONCLUSION: ranitidine 300 mg and nizatidine 300 mg both proved effective and safe in the treatment of acute peptic ulceration in the elderly.
Authors:
G Battaglia; F Di Mario; S Vigneri; P Dal Santo; A Pilotto; G Mazzacca
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-25     Completed Date:  1994-05-25     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
Double-Blind Method
Duodenal Ulcer / drug therapy*
Female
Humans
Male
Nizatidine / administration & dosage,  therapeutic use*
Ranitidine / administration & dosage,  therapeutic use*
Stomach Ulcer / drug therapy*
Chemical
Reg. No./Substance:
884KT10YB7/Ranitidine; P41PML4GHR/Nizatidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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