Document Detail

Peptic ulcer disease and the nonsteroidal anti-inflammatory drugs.
MedLine Citation:
PMID:  3994179     Owner:  NLM     Status:  MEDLINE    
The medical records of 265 patients with peptic ulcer disease were reviewed for a history of nonsteroidal anti-inflammatory drug (NSAID) use preceding hospital admission. Ninety-five patients (36%) gave a history of regular use of such agents. The admission characteristics of the peptic ulcer patient group not using NSAIDs (age, sex, ulcer location, admission indication, method of diagnosis) were virtually identical to those of the group taking NSAIDs. Although 24.5 per cent of patients not taking NSAIDs were admitted because of hemorrhage from their ulcer compared with 28.4 per cent of NSAID users, only 7.5 per cent of nonusers required surgery for hemorrhage control compared to 29.6 per cent of users. Eighty per cent of patients regularly using more than one NSAID required surgery for an ulcer complication. Hemorrhage mortality was 5 per cent among nonusers compared with 14.8 per cent among users. It is concluded that NSAID use by patients with peptic ulcers adversely affects therapeutic response in general and significantly impairs normal hemostatic mechanisms in patients bleeding from an ulcer.
J B Peoples
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  51     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-06-20     Completed Date:  1985-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  358-62     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / adverse effects*
Middle Aged
Peptic Ulcer / chemically induced*,  mortality,  therapy
Peptic Ulcer Hemorrhage / chemically induced*,  mortality,  therapy
Retrospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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