Document Detail


Pepsins, peptic activity, and peptic inhibitors.
MedLine Citation:
PMID:  6119339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our information about gastric pepsinogen secretion and peptic activity is incomplete because of the heterogeneity of pepsinogen and pepsin, and the lack of assays specific for the different pepsins in gastric juice. In general, the peptic activity of gastric juice parallels acid output, and the limited clinical information obtained from tests of gastric acid secretion is not enhanced by the determination of the peptic activity of gastric juice. Nevertheless, the inhibition of this activity is of prime importance in the pharmacotherapy of peptic ulcer disease. This can be accomplished by inhibiting the secretion of acid and pepsinogens, raising the pH of gastric juice, inhibiting the binding of pepsin to its substrate, adsorbing pepsin, or inhibiting the active site of pepsin. The first three strategies have been shown to be effective in accelerating the rate of healing of peptic ulcer.
Authors:
I M Samloff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  3     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antacids / pharmacology
Anti-Ulcer Agents / pharmacology*
Gastric Acid / secretion
Gastric Juice / secretion
Histamine H2 Antagonists / pharmacology
Humans
Hydrogen-Ion Concentration
Pepsin A / antagonists & inhibitors,  secretion*
Pepsinogens / antagonists & inhibitors,  secretion*
Pepstatins / pharmacology
Grant Support
ID/Acronym/Agency:
AM 13233/AM/NIADDK NIH HHS; AM 17328/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Antacids; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 0/Pepsinogens; 0/Pepstatins; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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