Document Detail


Pepsinogens and gastrointestinal symptoms in mountain marathon runners.
MedLine Citation:
PMID:  8973974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although there are various descriptive reports concerning exercise-induced gastrointestinal distress, the role of gastrointestinal hormones and/or enzymes is not definitively established. In this study we investigated the behaviour of pepsinogens (PGI and PGII) after an endurance race performed at an altitude of 4,300 m by 13 well-trained marathon runners, with the aim to establish their interrelationship with gastrointestinal distress and with the modifications of gastrin and cortisol. The athletes showed a significant rise in gastrin (p < 0.01) and in cortisol (p < 0.01) and a significant decrease in PGI (p < 0.01) and PGII (p < 0.05) after the race. The PGI/PGII ratio presented small variations indicating that heavy exercise has less effects on PGs than those observed for gastrin. Gastrointestinal symptoms occurred in 6 athletes (46%) during the race and in 8 athletes (62%) after the race. No relationship was found between gastrointestinal symptoms and hormonal modifications after the race. A control group of 5 subjects was used: they (n = 5) did not show any significant modification of gastrin and PGs during the period spent at the above altitude, indicating that travel, altitude and acclimatization, food and beverages, do not influence the behaviour of these hormones. Conversely, they presented a significant decrease of cortisol (p < 0.05) linked to the circadian rhythm. The data of the present study indicate that the potential damage of gastrointestinal apparatus in mountain marathon runners is not related to the above mentioned hormones.
Authors:
G Banfi; M Marinelli; P Bonini; I Gritti; G S Roi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  17     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  554-8     Citation Subset:  IM    
Affiliation:
Servizio Integrato di Medicina di Laboratorio, Istituto Scientifico H San Raffaele, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Altitude
Gastrins / blood*
Gastrointestinal Diseases / blood,  etiology*
Humans
Hydrocortisone / blood
Male
Pepsinogens / blood*
Radioimmunoassay
Reference Values
Running / physiology*
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Gastrins; 0/Pepsinogens; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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