Document Detail

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.
MedLine Citation:
PMID:  22304859     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Under- and overnutrition are associated with a worse prognosis and constitute independent risk factors for morbidity and mortality. It is increasingly important to understand the factors that affect nutritional and metabolic statuses. The purpose of this study was to assess the relation between the pepsinogen I/II ratio and several biochemical markers. METHODS: A cross-sectional study was performed in 1985 subjects who underwent a health screening test. Subjects had no medications for hyperuricemia, dyslipidemia, diabetes mellitus, or hypertension. All subjects were classified into two groups. Subjects with a pepsinogen I/II ratio below 3 were defined as having atrophic gastritis. The relations between the pepsinogen I/II ratio and several biochemical markers, including total cholesterol, triacylglycerol, uric acid, cholinesterase, and glucose levels, were evaluated. RESULTS: The presence of atrophic gastritis was significantly associated with age, smoking status, alcohol consumption, body mass index, and triacylglycerol, uric acid, cholinesterase, and hemoglobin levels. Multiple linear regression analysis demonstrated that the pepsinogen I/II ratio was an independent determinant of glucose level (β = 0.104, P < 0.0001), triacylglycerol level (β = 0.072, P = 0.0014), uric acid level (β = 0.048, P = 0.0138), and hemoglobin (β = 0.037, P = 0.0429) after adjustments for age, sex, smoking status, alcohol consumption, and body mass index. CONCLUSION: The pepsinogen I/II ratio was related to glucose, triacylglycerol, and uric acid levels. Such an association fosters the idea that a decreased pepsinogen I/II ratio seems favorable for the prevention of overnutrition.
Muhei Tanaka; Michiaki Fukui; Masaaki Kuroda; Masahiro Yamazaki; Goji Hasegawa; Yohei Oda; Yuji Naito; Hitoshi Toda; Toshikazu Yoshikawa; Naoto Nakamura
Related Documents :
5701689 - The glycerol teichoic acid from walls of staphylococcus epidermidis i2.
15178389 - Structural elucidation of the extracellular and cell-wall teichoic acids of staphylococ...
1252439 - The vitelline envelope of eggs from the giant keyhole limpet megathura crenulata. i. ch...
24891639 - Ruminal acidosis in a 21-month-old holstein heifer.
8119289 - Characterization of the lipopolysaccharide of moraxella catarrhalis. structural analysi...
3125849 - Isolation of type 5 capsular polysaccharide from staphylococcus aureus.
2995409 - A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cr...
16592449 - Organic acid and potassium accumulation in guard cells during stomatal opening.
12946139 - Efficient synthesis of enantiopure pyrrolizidinone amino acid.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-2
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  -     ISSN:  1873-1244     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Weight gain in long-term survivors of kidney or liver transplantation-Another paradigm of sarcopenic...
Next Document:  Obesity: From the Agricultural Revolution to the Contemporary Pediatric Epidemic.