| Pentylenetetrazol and reflex activity of isolated frog spinal cord. | |
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MedLine Citation:
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PMID: 306077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The superfused in vitro frog spinal cord preparation was used to investigate the effects of pentylenetetrazol (PTZ) on the spinal cord. PTZ depressed monosynaptic, but augmented polysynaptic reflexes, and decreased primary afferent deplorization. Concurrently, in Ringer's solution containing sufficient magnesium or cobalt ions to block synaptic transmission, PTZ antagonized the hyperpolarizing effects on motoneurons and the depolarizing effects on primary afferent fibers of the inhibitory amino acids GABA, beta-alanine, taurine, and glycine. PTZ did not affect responses to the excitatory amino acids glutamic acid and aspartic acid. Furthermore, PTZ did not alter high affinity uptake by cord slices, K+ -evoked release of [3H]GABA from them, or the spinal concentration of GABA. These data suggest that PTZ may produce its excitatory effects by postsynaptic blockade of inhibitory processes mediated by GABA (and possibly by other amino acids). |
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Authors:
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R A Davidoff; J C Hackman |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Neurology Volume: 28 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-06-12 Completed Date: 1978-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 488-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacology Animals Anura GABA Antagonists Membrane Potentials / drug effects Motor Neurons / drug effects Neurons, Efferent / drug effects Pentylenetetrazole / pharmacology* Rana pipiens Reflex / drug effects* Reflex, Monosynaptic / drug effects Spinal Cord / drug effects*, metabolism gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/GABA Antagonists; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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