Document Detail

Pentylenetetrazol and reflex activity of isolated frog spinal cord.
MedLine Citation:
PMID:  306077     Owner:  NLM     Status:  MEDLINE    
The superfused in vitro frog spinal cord preparation was used to investigate the effects of pentylenetetrazol (PTZ) on the spinal cord. PTZ depressed monosynaptic, but augmented polysynaptic reflexes, and decreased primary afferent deplorization. Concurrently, in Ringer's solution containing sufficient magnesium or cobalt ions to block synaptic transmission, PTZ antagonized the hyperpolarizing effects on motoneurons and the depolarizing effects on primary afferent fibers of the inhibitory amino acids GABA, beta-alanine, taurine, and glycine. PTZ did not affect responses to the excitatory amino acids glutamic acid and aspartic acid. Furthermore, PTZ did not alter high affinity uptake by cord slices, K+ -evoked release of [3H]GABA from them, or the spinal concentration of GABA. These data suggest that PTZ may produce its excitatory effects by postsynaptic blockade of inhibitory processes mediated by GABA (and possibly by other amino acids).
R A Davidoff; J C Hackman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  28     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  488-94     Citation Subset:  IM    
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MeSH Terms
Amino Acids / pharmacology
GABA Antagonists
Membrane Potentials / drug effects
Motor Neurons / drug effects
Neurons, Efferent / drug effects
Pentylenetetrazole / pharmacology*
Rana pipiens
Reflex / drug effects*
Reflex, Monosynaptic / drug effects
Spinal Cord / drug effects*,  metabolism
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Amino Acids; 0/GABA Antagonists; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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