Document Detail


Pentraxins and Fc receptors.
MedLine Citation:
PMID:  23046133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pentraxins are innate pattern recognition molecules whose major function is to bind microbial pathogens or cellular debris during infection and inflammation and, by doing so, contribute to the clearance of necrotic cells as well as pathogens through complement activations. Fc receptors are the cellular mediators of antibody functions. Although conceptually separated, both pentraxins and antibodies are important factors in controlling acute and chronic inflammation and infections. In recent years, increasing experimental evidence suggests a direct link between the innate pentraxins and humoral Fc receptors. Specifically, both human and mouse pentraxins recognize major forms of Fc receptors in solution and on cell surfaces with affinities similar to antibodies binding to their low affinity Fc receptors. Like immune complex, pentraxin aggregation and opsonization of pathogen result in Fc receptor and macrophage activation. The recently published crystal structure of human serum amyloid P (SAP) in complex with FcγRIIA further illustrated similarities to antibody recognition. These recent findings implicate a much broader role than complement activation for pentraxins in immunity. This review summarizes the structural and functional work that bridge the innate pentraxins and the adaptive Fc receptor functions. In many ways, pentraxins can be regarded as innate antibodies.
Authors:
Jinghua Lu; Kristopher D Marjon; Carolyn Mold; Terry W Du Clos; Peter D Sun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  230-8     Citation Subset:  IM    
Copyright Information:
Published 2012. This article is a US Government work and is in the public domain in the USA.
Affiliation:
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Animals
Antibodies / chemistry*,  immunology,  metabolism
Antigens, Bacterial / chemistry*,  immunology,  metabolism
C-Reactive Protein / chemistry*,  immunology,  metabolism
Complement Activation
Humans
Immunity, Innate
Inflammation / immunology
Mice
Models, Molecular
Protein Binding
Protein Structure, Tertiary
Receptors, IgG / chemistry*,  immunology,  metabolism
Serum Amyloid P-Component / chemistry*,  immunology,  metabolism
Grant Support
ID/Acronym/Agency:
R21AI085414./AI/NIAID NIH HHS; UL1 TR000041/TR/NCATS NIH HHS; Z01 AI000853-09/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens, Bacterial; 0/Fc gamma receptor IIA; 0/Receptors, IgG; 0/Serum Amyloid P-Component; 9007-41-4/C-Reactive Protein
Comments/Corrections

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