| Pentraxins and Alzheimer's disease: At the interface between biomarkers and pharmacological targets. | |
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MedLine Citation:
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PMID: 22186030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of activated microglia and by an excessive amount of neuroinflammatory components such as cytokines and acute-phase proteins. This review aims to shed light on the role of the immune processes involved in AD, focusing on a family of inflammatory modulators belonging to the acute-phase proteins and crucial components of the humoral arm of innate immunity: pentraxins. In particular we analyze function of the pentraxins in AD, their upregulation in the brain and their contribution to neurodegeneration. Additionally, we highlight the role of pentraxins as putative AD biomarkers and as pharmacological therapeutic targets. |
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Authors:
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Cecilia Osera; Alessia Pascale; Marialaura Amadio; Letizia Venturini; Stefano Govoni; Giovanni Ricevuti |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Ageing research reviews Volume: - ISSN: 1872-9649 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128963 Medline TA: Ageing Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Drug Sciences, Section of Pharmacology, Laboratory of Neurobiology and Neuropharmacology of Neurodegenerative Diseases and the Nervous System, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy. |
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