Document Detail

Pentraxin 3 is elevated in haemodialysis patients and is associated with cardiovascular disease.
MedLine Citation:
PMID:  17496115     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pentraxins are mediators of inflammation as well as markers of the acute-phase reaction. While elevation of C-reactive protein (CRP) in patients with renal failure and its association with cardiovascular disease is well described, there are no data on pentraxin 3 (PTX3) in this population. METHODS: Plasma was obtained from 44 chronic haemodialysis (HD) patients, 35 peritoneal dialysis (PD) patients, 39 patients with chronic renal failure (CRF) not on dialysis therapy and 14 age-matched normal subjects. PTX3 production in whole blood was also investigated in samples taken before and during HD. RESULTS: PTX3 plasma levels were significantly higher in HD patients (5.8 +/- 0.6 ng/ml) compared with the other three groups. There were no significant differences between PD patients (1.5 +/- 0.4 ng/ml), CRF patients (1.5 +/- 0.4 ng/ml) and normal subjects (0.76 +/- 0.2 ng/ml). In dialysis patients, PTX3 levels correlated significantly with time on renal replacement therapy (RRT) and with weekly erythropoietin dose. PTX3 levels were significantly higher in patients with coronary artery disease and peripheral artery disease compared with those without. During a single HD session, PTX3 production was higher in whole blood samples taken after 3 h HD compared with samples taken before HD. CONCLUSIONS: PTX3 levels are markedly elevated in HD patients. The increase in PTX3 production in whole blood after HD indicates that the HD procedure itself contributes to elevated PTX3 levels in HD patients. The association between PTX3 and cardiovascular morbidity suggests a possible connection of PTX3 with atherosclerosis and cardiovascular disease in HD patients.
Michael Boehme; Fenja Kaehne; Anna Kuehne; Wanja Bernhardt; Matthias Schröder; Wolfgang Pommer; Christoph Fischer; Helmut Becker; Christian Müller; Ralf Schindler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-11
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  22     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-11-07     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2224-9     Citation Subset:  IM    
Department of Nephrology and Intensive Care Medicine, Charité, Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin.
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MeSH Terms
C-Reactive Protein / biosynthesis*
Cardiovascular Diseases / blood*,  diagnosis*
Interleukin-6 / blood
Models, Statistical
Peritoneal Dialysis
Renal Dialysis*
Serum Amyloid P-Component / biosynthesis*
Reg. No./Substance:
0/Interleukin-6; 0/Serum Amyloid P-Component; 148591-49-5/PTX3 protein; 9007-41-4/C-Reactive Protein
Comment In:
Nephrol Dial Transplant. 2009 Mar;24(3):1064-5; author reply 1065-6   [PMID:  19110487 ]

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