| Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. | |
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MedLine Citation:
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PMID: 21391986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and to predict adverse outcomes in individuals with cardiovascular disease (CVD). Despite being a member of the same pentraxin protein family as C-reactive protein (CRP), PTX3 probably reflects different aspects of CVD pathogenesis. In this study, we assessed plasma PTX3 correlates and determinants in the Health 2000 Survey population, which comprised n = 403 insulin-resistant subjects, n = 845 hypercholesterolaemic subjects and n = 311 hypertensive subjects, all aged between 46 and 76 years. In insulin-resistant subjects the PTX3 concentration was found to correlate directly with age, pulse pressure and indoleamine 2,3-dioxygenase (IDO) enzyme activity and inversely with total and low-density lipoprotein (LDL) cholesterol. In hypercholesterolaemic subjects, the PTX3 concentration correlated directly with HDL cholesterol, systolic blood pressure and pulse pressure, whereas in hypertensive subjects, the PTX3 concentration correlated directly with systolic blood pressure, pulse pressure and IDO activity. No correlation was observed between the concentrations of PTX3 and CRP, adiposity indicators or indicators of subclinical atherosclerosis in any of the subject groups. PTX3 concentration variations were attributed to variations in LDL cholesterol and IDO activity in insulin-resistant subjects and to pulse pressure in hypercholesterolaemic and hypertensive subjects. These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis. |
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Authors:
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J Jylhävä; A Haarala; M Kähönen; T Lehtimäki; A Jula; L Moilanen; Y A Kesäniemi; M S Nieminen; M Hurme |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-10 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 164 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-11 Completed Date: 2011-06-14 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Department of Microbiology and Immunology, Medical School, University of Tampere, Finland. juulia.jylhava@uta.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Anthropometry Biological Markers Blood Pressure C-Reactive Protein / analysis* Cardiovascular Diseases / epidemiology* Carotid Arteries / ultrasonography Cholesterol / blood Cross-Sectional Studies Female Finland / epidemiology Humans Hypercholesterolemia / blood Hypertension / blood Indoleamine-Pyrrole 2,3,-Dioxygenase / blood Insulin Resistance Male Middle Aged Risk Factors Serum Amyloid P-Component / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Serum Amyloid P-Component; 148591-49-5/PTX3 protein; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein; EC 1.13.11.42/Indoleamine-Pyrrole 2,3,-Dioxygenase |
| Comments/Corrections | |
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