| Pentoxyphylline in association with vitamin E reduces cutaneous fibrosis in systemic sclerosis. | |
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MedLine Citation:
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PMID: 19468787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis (SSc) is a disorder characterized by skin thickness and vasculopathy. The objective of the study was to evaluate the therapeutic effect and safety of the association of pentoxyphylline and vitamin E in SSc patients. Twelve SSc patients (American College of Rheumatology criteria) enrolled this 24-week open-label study. Patients received daily 800 mg of pentoxyphylline and 800 UI of vitamin E and were evaluated at 4-week interval. The primary efficacy endpoint was the change in Modified Rodnan Skin Score (MRSS) at week 24. Nine diffuse SSc patients treated 6 months with cyclophosphamide were used as a historical control group. The mean age of the treated group was 43.6 years, and ten of 12 (84%) patients were women. Their mean MRSS reduced from 25.7 to 18.7 (p = 0.03) at 16th week and remained significantly reduced throughout the study. In contrast, only a trend of MRSS reduction was observed in the historical control group (p = 0.06). Two patients started the study with active ischemic ulcers and ended with a complete healing of them. No serious side effects were reported. Pentoxyphylline and vitamin E might be an alternative therapeutic approach in SSc patients. |
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Authors:
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Romy Beatriz Christmann de Souza; Andr?? Regis Macedo; K??tia Akemi Kuruma; Patricia Andrade Macedo; Claudia Teresa Lobato Borges |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2009-05-26 |
Journal Detail:
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Title: Clinical rheumatology Volume: 28 ISSN: 1434-9949 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-03 Completed Date: 2010-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Germany |
Other Details:
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Languages: eng Pagination: 1207-12 Citation Subset: IM |
Affiliation:
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Rheumatology Division, Medical School, University of S??o Paulo, Av. Dr. Arnaldo 455, 30 andar, S??o Paulo, SP, 01246-903, Brazil. romy.souza@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / adverse effects, therapeutic use* Drug Therapy, Combination Female Fibrosis Humans Male Middle Aged Pentoxifylline / adverse effects, therapeutic use* Scleroderma, Systemic / drug therapy*, pathology* Skin / pathology* Treatment Outcome Vasodilator Agents / adverse effects, therapeutic use* Vitamin E / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Vasodilator Agents; 1406-18-4/Vitamin E; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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