| Pentoxifylline improves tissue oxygenation following anesthesia and operation. | |
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MedLine Citation:
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PMID: 3802870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pentoxifylline has been shown to increase red blood cell malleability, thus increasing capillary blood flow in a number of disease states. The present study was undertaken to determine whether pentoxifylline might improve tissue oxygenation after anesthesia and during an operation in rats. Rats were anesthetized and divided randomly into pentoxifylline (injected with pentoxifylline) and control (injected with normal saline) groups. Thirty minutes later, midline laparotomy was performed, and surface oxygen tensions and surface temperatures were measured on stomach, liver, cecum, urinary bladder, and anterior abdominal wall. Simultaneously, the mean arterial pressure (MAP) and core temperature were measured. PaO2 was then measured. In the pentoxifylline-treated rats, tissue oxygen tensions were significantly higher than in saline-treated rats. Statistically, there was no significant difference in MAP during these measurements, no difference in either core or organ surface temperatures, and no significant difference in PaO2. |
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Authors:
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M H Soliman; K O'Neal; K Waxman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care medicine Volume: 15 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-13 Completed Date: 1987-03-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Animals Blood Pressure / drug effects Body Temperature / drug effects Male Oximetry Oxygen / metabolism* Partial Pressure Pentoxifylline / pharmacology* Postoperative Period Rats Rats, Inbred Strains Theobromine / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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6493-05-6/Pentoxifylline; 7782-44-7/Oxygen; 83-67-0/Theobromine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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