Document Detail

Pentavalent human-bovine (WC3) reassortant rotavirus vaccine in special populations: a review of data from the Rotavirus Efficacy and Safety Trial.
MedLine Citation:
PMID:  18351405     Owner:  NLM     Status:  MEDLINE    
Rotavirus gastroenteritis is a disease that causes significant morbidity and mortality worldwide in infants and children. The recent availability of efficacious rotavirus vaccines with favorable safety profiles has prompted medical agencies around the world to register the vaccines and countries and regions to recommend universal vaccination of healthy infants to prevent the serious health and economic consequences of rotavirus illness in children. Premature infants can be especially vulnerable to severe rotavirus infections, which may lead to serious outcomes. The clinical efficacy and safety of the pentavalent human-bovine rotavirus vaccine (PRV, RotaTeq, Merck, Whitehouse Station, NJ, USA) in healthy infants has been evaluated in the large phase III Rotavirus Efficacy and Safety Trial (REST). Preterm (N = 2,070) and exclusively breastfed infants (N = 1,566) were included in this study. The efficacy and safety of PRV in premature infants and in breastfed infants from the REST database are reviewed along with guidelines from national medical organizations for the use of PRV in these populations. Based on these data from the REST study, premature infants receive the same protection from PRV compared with nonpremature infants, without additional safety risk. Similarly, breastfed and nonbreastfed infants are equally protected from severe consequences of rotavirus gastroenteritis.
M Van der Wielen; P Van Damme
Related Documents :
19932945 - Maternal psychological impact of medical information in the neonatal period after prema...
7485345 - Premature parturition is characterized by in utero activation of the fetal immune system.
11617225 - Premature mortality in the republic of ireland.
3341325 - Tracheal stenosis in the sick premature infant. clinical and radiologic features.
10194995 - Influence of erythromycin on establishment of feeding in preterm infants: observations ...
11518155 - Infant sensitivity to trajectory forms.
Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-20
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  27     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  495-501     Citation Subset:  IM    
Faculty of Medicine, University of Antwerp, Universiteitsplein, 1, 2610, Wilrijk, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast Feeding
Child, Preschool
Clinical Trials as Topic
Infant, Newborn
Infant, Premature
Practice Guidelines as Topic
Rotavirus Infections / epidemiology*,  prevention & control*
Rotavirus Vaccines / adverse effects*,  immunology*
Reg. No./Substance:
0/Rotavirus Vaccines; 0/WC3 rotavirus vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The molecular structure of a curl-shaped retinal isomer.
Next Document:  Using color power Doppler ultrasound imaging to diagnose the acute scrotum. A pictorial essay.