| Pentavalent human-bovine (WC3) reassortant rotavirus vaccine in special populations: a review of data from the Rotavirus Efficacy and Safety Trial. | |
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MedLine Citation:
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PMID: 18351405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rotavirus gastroenteritis is a disease that causes significant morbidity and mortality worldwide in infants and children. The recent availability of efficacious rotavirus vaccines with favorable safety profiles has prompted medical agencies around the world to register the vaccines and countries and regions to recommend universal vaccination of healthy infants to prevent the serious health and economic consequences of rotavirus illness in children. Premature infants can be especially vulnerable to severe rotavirus infections, which may lead to serious outcomes. The clinical efficacy and safety of the pentavalent human-bovine rotavirus vaccine (PRV, RotaTeq, Merck, Whitehouse Station, NJ, USA) in healthy infants has been evaluated in the large phase III Rotavirus Efficacy and Safety Trial (REST). Preterm (N = 2,070) and exclusively breastfed infants (N = 1,566) were included in this study. The efficacy and safety of PRV in premature infants and in breastfed infants from the REST database are reviewed along with guidelines from national medical organizations for the use of PRV in these populations. Based on these data from the REST study, premature infants receive the same protection from PRV compared with nonpremature infants, without additional safety risk. Similarly, breastfed and nonbreastfed infants are equally protected from severe consequences of rotavirus gastroenteritis. |
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Authors:
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M Van der Wielen; P Van Damme |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-03-20 |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 27 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 495-501 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, University of Antwerp, Universiteitsplein, 1, 2610, Wilrijk, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Feeding Child, Preschool Clinical Trials as Topic Humans Infant Infant, Newborn Infant, Premature Practice Guidelines as Topic Rotavirus Infections / epidemiology*, prevention & control* Rotavirus Vaccines / adverse effects*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Rotavirus Vaccines; 0/WC3 rotavirus vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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