Document Detail


Pentavalent human-bovine (WC3) reassortant rotavirus vaccine in special populations: a review of data from the Rotavirus Efficacy and Safety Trial.
MedLine Citation:
PMID:  18351405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rotavirus gastroenteritis is a disease that causes significant morbidity and mortality worldwide in infants and children. The recent availability of efficacious rotavirus vaccines with favorable safety profiles has prompted medical agencies around the world to register the vaccines and countries and regions to recommend universal vaccination of healthy infants to prevent the serious health and economic consequences of rotavirus illness in children. Premature infants can be especially vulnerable to severe rotavirus infections, which may lead to serious outcomes. The clinical efficacy and safety of the pentavalent human-bovine rotavirus vaccine (PRV, RotaTeq, Merck, Whitehouse Station, NJ, USA) in healthy infants has been evaluated in the large phase III Rotavirus Efficacy and Safety Trial (REST). Preterm (N = 2,070) and exclusively breastfed infants (N = 1,566) were included in this study. The efficacy and safety of PRV in premature infants and in breastfed infants from the REST database are reviewed along with guidelines from national medical organizations for the use of PRV in these populations. Based on these data from the REST study, premature infants receive the same protection from PRV compared with nonpremature infants, without additional safety risk. Similarly, breastfed and nonbreastfed infants are equally protected from severe consequences of rotavirus gastroenteritis.
Authors:
M Van der Wielen; P Van Damme
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-20
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  27     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  495-501     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, University of Antwerp, Universiteitsplein, 1, 2610, Wilrijk, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Child, Preschool
Clinical Trials as Topic
Humans
Infant
Infant, Newborn
Infant, Premature
Practice Guidelines as Topic
Rotavirus Infections / epidemiology*,  prevention & control*
Rotavirus Vaccines / adverse effects*,  immunology*
Chemical
Reg. No./Substance:
0/Rotavirus Vaccines; 0/WC3 rotavirus vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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