| Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT. | |
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MedLine Citation:
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PMID: 8504275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following BMT there is a 5-15% risk of interstitial pneumonia caused by Pneumocystis carinii (PcP). Cotrimoxazole is therefore administered prophylactically, but may cause myelodepression, allergic reactions and nephrotoxicity. As PcP prophylaxis with pentamidine aerosol is effective in patients with AIDS, we conducted a prospective trial with regular inhalations of pentamidine. The aim of this study was to evaluate toxicity, safety, practicability and possible resorption of aerosolized pentamidine. We treated 31 allogeneic and 12 autologous BMT patients with 60 mg pentamidine 3 days before and 14 days after BMT. Starting 4 weeks after BMT, 300 mg pentamidine was given every 4 weeks for 6 months. There was no pneumonia caused by Pneumocystis carinii. The only noteworthy side-effects were cough (19.8%), salivation (9.6%), and sore throat (5.7%), of similar frequency after allogeneic or autologous BMT. Using high pressure liquid chromatography, pentamidine could only be detected in the serum of 33-54% of patients tested. In these patients the median serum levels were 7.5-9 ng/ml. We conclude that pentamidine aerosol has only minor side-effects, is well tolerated and safe, and is therefore an attractive alternative for PcP prophylaxis after BMT. |
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Authors:
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H Link; H F Vöhringer; F Wingen; B Brägas; A Schwardt; G Ehninger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 11 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-08 Completed Date: 1993-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 403-6 Citation Subset: IM; X |
Affiliation:
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Department of Haematology and Oncology, Medizinische Hochschule, Hannover, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Bone Marrow Transplantation* Female Hodgkin Disease / therapy Humans Leukemia / therapy Lymphoma, Non-Hodgkin / therapy Male Middle Aged Pentamidine / administration & dosage*, adverse effects, blood, urine Pneumonia, Pneumocystis / prevention & control* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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100-33-4/Pentamidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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