Document Detail


Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT.
MedLine Citation:
PMID:  8504275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following BMT there is a 5-15% risk of interstitial pneumonia caused by Pneumocystis carinii (PcP). Cotrimoxazole is therefore administered prophylactically, but may cause myelodepression, allergic reactions and nephrotoxicity. As PcP prophylaxis with pentamidine aerosol is effective in patients with AIDS, we conducted a prospective trial with regular inhalations of pentamidine. The aim of this study was to evaluate toxicity, safety, practicability and possible resorption of aerosolized pentamidine. We treated 31 allogeneic and 12 autologous BMT patients with 60 mg pentamidine 3 days before and 14 days after BMT. Starting 4 weeks after BMT, 300 mg pentamidine was given every 4 weeks for 6 months. There was no pneumonia caused by Pneumocystis carinii. The only noteworthy side-effects were cough (19.8%), salivation (9.6%), and sore throat (5.7%), of similar frequency after allogeneic or autologous BMT. Using high pressure liquid chromatography, pentamidine could only be detected in the serum of 33-54% of patients tested. In these patients the median serum levels were 7.5-9 ng/ml. We conclude that pentamidine aerosol has only minor side-effects, is well tolerated and safe, and is therefore an attractive alternative for PcP prophylaxis after BMT.
Authors:
H Link; H F Vöhringer; F Wingen; B Brägas; A Schwardt; G Ehninger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  11     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-08     Completed Date:  1993-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM; X    
Affiliation:
Department of Haematology and Oncology, Medizinische Hochschule, Hannover, Germany.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Bone Marrow Transplantation*
Female
Hodgkin Disease / therapy
Humans
Leukemia / therapy
Lymphoma, Non-Hodgkin / therapy
Male
Middle Aged
Pentamidine / administration & dosage*,  adverse effects,  blood,  urine
Pneumonia, Pneumocystis / prevention & control*
Prospective Studies
Chemical
Reg. No./Substance:
100-33-4/Pentamidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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