Document Detail


Pentagastrin stimulates epithelial cell proliferation in duodenal and colonic crypts in fasted rats.
MedLine Citation:
PMID:  992276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In fasted rats, single injection of pentagastrin (250 mug/kg) stimulates epithelial cell proliferation in the duodenum and colon, but not in the esophagus. Fasting for 64 hours suppresses cell proliferation more markedly in colonic crypts than in duodenal crypts, and pentagastrin restores the cell proliferative activity of the colon and duodenum to levels comparable with those of fed rats. In both duodenal and colonic crypts, differentiating-proliferative cells in the mid-portion of the crypts are more responsive to pentagastrin stimulation than immature proliferative cells at the base of the crypts. Non-dividing epithelial cells are not affected. Pentagastrin has no influence on cell proliferation in fed rats.
Authors:
K M Mak; W W Chang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  71     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1117-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / drug effects
Colon / cytology*
Duodenum / cytology*
Epithelial Cells
Epithelium / drug effects
Esophagus / cytology
Fasting
Intestinal Mucosa / cytology*
Male
Pentagastrin / pharmacology*
Rats
Stimulation, Chemical
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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