| Pentagastrin stimulates epithelial cell proliferation in duodenal and colonic crypts in fasted rats. | |
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MedLine Citation:
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PMID: 992276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In fasted rats, single injection of pentagastrin (250 mug/kg) stimulates epithelial cell proliferation in the duodenum and colon, but not in the esophagus. Fasting for 64 hours suppresses cell proliferation more markedly in colonic crypts than in duodenal crypts, and pentagastrin restores the cell proliferative activity of the colon and duodenum to levels comparable with those of fed rats. In both duodenal and colonic crypts, differentiating-proliferative cells in the mid-portion of the crypts are more responsive to pentagastrin stimulation than immature proliferative cells at the base of the crypts. Non-dividing epithelial cells are not affected. Pentagastrin has no influence on cell proliferation in fed rats. |
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Authors:
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K M Mak; W W Chang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 71 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1976 Dec |
Date Detail:
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Created Date: 1977-01-25 Completed Date: 1977-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1117-20 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects Colon / cytology* Duodenum / cytology* Epithelial Cells Epithelium / drug effects Esophagus / cytology Fasting Intestinal Mucosa / cytology* Male Pentagastrin / pharmacology* Rats Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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