Document Detail

Penile and scrotum swelling in juvenile dermatomyositis.
MedLine Citation:
PMID:  21841738     Owner:  NLM     Status:  Publisher    
Edema is a well-known feature of juvenile dermatomyositis (JDM). However, to our knowledge localized penile and scrotum swelling was not previously reported. During a 27-year period, 5,506 patients were followed up at the Pediatric Rheumatology Unit of our University Hospital and 157 patients (2.9%) had JDM. One of them (0.6%) had concomitant localized penile and scrotum swelling. He had severe disease activity since he was 7-year-old, manifested by diffuse cutaneous vasculitis, recurrent localized edema (limbs or face) and only one episode of generalized edema. At the age of 10, he presented edema of the genitalia associated with mild skin erythema. Penis, scrotum and testicular ultrasound as well as magnetic resonance imaging showed skin edema without testicular involvement. He was taking prednisone, methotrexate, cyclosporin, hydroxychloroquine and thalidomide. Improvement of skin rash, penile and scrotum swelling was noticed only with rituximab therapy. No adverse event was observed during anti-CD20 infusions and after six months of follow up. Penile and scrotum edema was a rare manifestation of JDM which improved with anti-CD20 monoclonal antibody treatment.
A M Elias Sallum; M F Castro Silva; C M Michelin; R J Duarte; R Hueb Baroni; N E Aikawa; C A Silva
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Publication Detail:
Journal Detail:
Title:  Acta reumatologica portuguesa     Volume:  36     ISSN:  0303-464X     ISO Abbreviation:  -     Publication Date:    2011 Abr-Jun
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431702     Medline TA:  Acta Reumatol Port     Country:  -    
Other Details:
Languages:  ENG     Pagination:  176-179     Citation Subset:  -    
Vernacular Title:
Penile and scrotum swelling in juvenile dermatomyositis.
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