Document Detail


Penile intraepithelial neoplasia: results of photodynamic therapy.
MedLine Citation:
PMID:  16955186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to study the results of photodynamic therapy in the treatment of penile intraepithelial neoplasia in men over the age of 40 years. Ten patients aged 42-82 years with histopathologically confirmed lesions were studied. Lesions initially responded to photo-dynamic therapy in 7 out of 10 patients. Four of these patients presented no recurrences during a mean follow-up of 35 months, and were completely cleared after 2-8 treatments (mean 4.5 treatments). Three patients presented recurrences after treatment. No patient developed invasive penile cancer (mean follow-up 46.5 months). Photodynamic therapy is an alternative in the treatment of penile intraepithelial neoplasia, although prospective randomized trials are required to provide therapeutic guidelines.
Authors:
John Paoli; Annika Ternesten Bratel; Gun-Britt Löwhagen; Bo Stenquist; Ola Forslund; Ann-Marie Wennberg
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  86     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Venereology, Sahlgrenska University Hospital, SE-41345 Göteborg, Sweden. john.paoli@vgregion.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Papillomaviridae / isolation & purification
Papillomavirus Infections
Penile Neoplasms / drug therapy*,  virology
Photochemotherapy*
Precancerous Conditions / drug therapy*,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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