Document Detail


Penicillin or vancomycin plus ceftazidime in febrile neutropenic patients after stem cell transplantation.
MedLine Citation:
PMID:  11109643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The response of gram-positive cocci to third generation cephalosporin therapy in febrile neutropenic patients is not optimal. We evaluated the safety and efficacy of ceftazidime plus penicillin (C + P) and compared it to ceftazidime plus vancomycin (C + V) in febrile neutropenic patients. The study includes 64 patients admitted to the Department of Haematology. Thirty-six patients were treated with C + V and 28 patients with C + P. Control of infection was observed in 78% of the patients in the C + V group and in 57% of the patients in C + P group (p = 0.5). Infection was the cause of the death of 1 patient in each group. We conclude that the combination of C + P has the same activity as the combination of C + V in febrile neutropenic patients. The morbidity and mortality were identical in both groups but cost effectiveness was in favour of the C + P group.
Authors:
K Kargar Samani; B Vandercam; N Straetmans; L Michaux; A Ferrant
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  55     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2000-12-13     Completed Date:  2000-12-28     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Bacteremia / drug therapy,  microbiology
Bone Marrow Transplantation
Ceftazidime / administration & dosage,  therapeutic use*
Cephalosporins / administration & dosage,  therapeutic use*
Chi-Square Distribution
Drug Combinations
Female
Fever / drug therapy*
Gram-Positive Bacterial Infections / drug therapy
Hematopoietic Stem Cell Transplantation*
Humans
Male
Middle Aged
Neutropenia / drug therapy*
Penicillins / administration & dosage,  therapeutic use*
Retrospective Studies
Safety
Staphylococcal Infections / drug therapy
Treatment Outcome
Vancomycin / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Drug Combinations; 0/Penicillins; 6Q205EH1VU/Vancomycin; 9M416Z9QNR/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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