Document Detail

Penicillin transport from cerebrospinal fluid.
MedLine Citation:
PMID:  988504     Owner:  NLM     Status:  MEDLINE    
The passage of penicillin G from cerebrospinal fluid (CSF) was studied by continuous ventriculocisternal perfusion in conscious rabbits. The concentration of penicillin G in the perfusate, collected from the cisterna magna, was 76.5 percent +/- 1.0 (SEM) of that entering the ventricles (having adjusted for normal secretion of CSF). The mean concentration of penicillin G rose 15 percent (p less than 0.005) in the cisternal CSF after probenecid (2 mg per milliliter) was added to the perfusion fluid. We conclude that an active transport system removes penicillin G from the CSF; this mechanism can be inhibited by intraventricular probenecid. Our results are in accord with observations deriving from studies on anesthetized animals given probenecid intravenously or intraperitoneally.
I N Walters; P F Teychenne; L E Claveria; D B Calne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  26     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1008-10     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active / drug effects
Cerebral Ventricles / drug effects,  metabolism
Penicillin G / cerebrospinal fluid*,  metabolism
Probenecid / pharmacology
Reg. No./Substance:
57-66-9/Probenecid; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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