Document Detail


Penicillin and cephalosporin drug allergies: a paradigm shift.
MedLine Citation:
PMID:  19017859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Medication hypersensitivity is a constant variable that podiatric physicians face during their professional day. To avoid potential patient harm, an understanding of penicillin and cephalosporin hypersensitivities as it pertains to podiatric medicine needs to be achieved. To accomplish this, a narrative describing the signs, symptoms, and immunologic mechanisms for the basis of penicillin and cephalosporin drug hypersensitivities is presented. Second, specific medical literature serving as clinical-based evidence to support the prescribing of cephalosporins in patients with documented penicillin allergy is presented. Finally, a review of the medical and legal literature describing health-care provider liability regarding subsequent drug hypersensitivity is presented. The information contained in this review allows for the evolving paradigm that permits the prescribing of selective cephalosporins to patients with a history of penicillin allergy as long as the allergic symptoms were not serious or life-threatening.
Authors:
Robert G Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Podiatric Medical Association     Volume:  98     ISSN:  8750-7315     ISO Abbreviation:  J Am Podiatr Med Assoc     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501423     Medline TA:  J Am Podiatr Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-88     Citation Subset:  IM    
Affiliation:
Shoe String Podiatry, 723 Lucerne Cir, Ormond Beach, FL 32174, USA. Robert.Smith@FHMD.org
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / adverse effects*
Cephalosporins / adverse effects*
Drug Hypersensitivity / diagnosis,  epidemiology*,  prevention & control
Humans
Liability, Legal*
Penicillins / adverse effects*
Podiatry*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Penicillins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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