Document Detail

Penicillin G versus cefuroxime for prophylaxis in lower limb amputation.
MedLine Citation:
PMID:  3327354     Owner:  NLM     Status:  MEDLINE    
Out of 457 patients amputated below or above the knee, we randomized 288 to receive penicillin G and 229 cefuroxime as prophylaxis against infection. We also stratified the patients into two groups: Group A (313 patients) who did not receive antibiotic treatment within 48 hours prior to the operation and Group B (88 patients) who did. There were 56 dropouts according to protocol regulations. The patients were evaluated for efficacy on the 21st postoperative day. In Group A, 20 of 158 (13 per cent) penicillin G-treated and 27 of 155 (17 per cent) cefuroxime-treated had wound sepsis; 5 (3 per cent) penicillin G-treated and 4 (3 per cent) cefuroxime-treated patients had been reamputated by Day 21 (P greater than 0.05). We concluded that prophylactic penicillin G prevents infection as effectively as cefuroxime after lower limb amputation.
H Friis
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  58     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-12     Completed Date:  1988-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  666-8     Citation Subset:  IM    
Department of Clinical Microbiology, University of Copenhagen, Copenhagen County Hospitals, Herlev, Denmark.
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MeSH Terms
Aged, 80 and over
Cefuroxime / administration & dosage,  therapeutic use*
Cephalosporins / therapeutic use*
Clinical Trials as Topic
Leg / surgery*
Middle Aged
Penicillin G / administration & dosage,  therapeutic use*
Random Allocation
Surgical Wound Infection / prevention & control*
Reg. No./Substance:
0/Cephalosporins; 55268-75-2/Cefuroxime; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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