| Penicillamine treatment in rheumatoid arthritis. A retrospective study. | |
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MedLine Citation:
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PMID: 7368979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Out of 64 patients with rheumatoid arthritis (RA), 42 were treated with D-penicillamine (D-Pa) for more than 6 months and 22 for less than 6 months. The latter patients were excluded from the evaluation of the effect. The former patients were treated with doses of 600-1 250 mg daily for 6-41 months (mean 16.8). The clinical effect was retrospectively assessed as favourable in 24 patients, 12 did not respond and the effect could not be assessed in 6. The clinical assessment was supported by significant reductions of ESR and orosomucoid. Adverse reactions, although rarely serious, led to withdrawal of the drug in 25 (39%) of the 64 patients. It is concluded that D-Pa is a valuable drug in the treatment of severe RA. |
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Authors:
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O Börjesson; L P Knutsson; B Svensson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 207 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1980 |
Date Detail:
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Created Date: 1980-06-16 Completed Date: 1980-06-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / drug therapy* Blood Sedimentation Female Humans Male Middle Aged Orosomucoid / analysis Penicillamine / administration & dosage, adverse effects, therapeutic use* Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Orosomucoid; 52-67-5/Penicillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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