Document Detail

Penicillamine treatment in rheumatoid arthritis. A retrospective study.
MedLine Citation:
PMID:  7368979     Owner:  NLM     Status:  MEDLINE    
Out of 64 patients with rheumatoid arthritis (RA), 42 were treated with D-penicillamine (D-Pa) for more than 6 months and 22 for less than 6 months. The latter patients were excluded from the evaluation of the effect. The former patients were treated with doses of 600-1 250 mg daily for 6-41 months (mean 16.8). The clinical effect was retrospectively assessed as favourable in 24 patients, 12 did not respond and the effect could not be assessed in 6. The clinical assessment was supported by significant reductions of ESR and orosomucoid. Adverse reactions, although rarely serious, led to withdrawal of the drug in 25 (39%) of the 64 patients. It is concluded that D-Pa is a valuable drug in the treatment of severe RA.
O Börjesson; L P Knutsson; B Svensson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  207     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1980  
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / drug therapy*
Blood Sedimentation
Middle Aged
Orosomucoid / analysis
Penicillamine / administration & dosage,  adverse effects,  therapeutic use*
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Orosomucoid; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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