Document Detail


Penetration of prophylactic antibiotics into peritoneal fluid.
MedLine Citation:
PMID:  2658640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluates the penetration of cephalosporins into the peritoneal fluid. Forty-six patients scheduled for abdominal surgery were randomized into three groups. On call to the operating room each patient was given a single 1 g dose of cefazolin, cefuroxime, or ceftazidime. Samples of the peritoneal fluid and blood were simultaneously obtained immediately after opening the peritoneal cavity. The mean serum cefazolin concentration was the highest. High peritoneal fluid levels of all three antibiotics were found; however, the antibacterial activity against common intestinal pathogens varied significantly. Cefazolin is the only study drug that possesses marginal in vitro activity against Streptococcus faecalis, a species generally considered resistent to cephalosporins. This study suggests that prophylactic second and third generation cephalosporins are not superior to cefazolin.
Authors:
O Kaplan; S Berger; A Gorea; R R Rozin; S Lelcuk
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of surgery     Volume:  157     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Hadassah Hospital, Tel Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Abdomen / surgery
Aged
Ascitic Fluid / metabolism*
Cefazolin / pharmacokinetics
Ceftazidime / pharmacokinetics
Cefuroxime / pharmacokinetics
Cephalosporins / administration & dosage,  pharmacokinetics*
Female
Humans
Male
Middle Aged
Premedication*
Surgical Wound Infection / prevention & control
Chemical
Reg. No./Substance:
0/Cephalosporins; 25953-19-9/Cefazolin; 55268-75-2/Cefuroxime; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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