Document Detail


Penetration and enrichment of flufenamic acid in calf skin from patients with stasis dermatitis.
MedLine Citation:
PMID:  1980985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the hypothesis that the application of medicaments to skin from the lower leg of patients with stasis dermatitis might lead to their enhanced enrichment, compared with uninvolved skin from the same region, a penetration study was performed with flufenamic acid. In 5 patients with pronounced changes of chronic venous insufficiency and in 5 control patients without chronic venous insufficiency the flufenamic acid content in skin sections parallel to the surface was determined by HPLC. In chronic venous insufficiency-skin, the flufenamic acid concentration was higher in all skin levels compared to control skin. This enrichment of the substance could lead to a prolonged and more intense contact with antigen-presenting cells in this region, thus promoting the development of contact allergies observed so frequently in this pathologic condition.
Authors:
F A Bahmer; H Loth; T Wild
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  70     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-20     Completed Date:  1991-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of the Saarland, Saarbrücken, FRG.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chromatography, High Pressure Liquid
Chronic Disease
Dermatitis / metabolism*
Female
Flufenamic Acid / pharmacokinetics*
Humans
Leg
Male
Middle Aged
Permeability
Skin / metabolism*
Venous Insufficiency / metabolism
Chemical
Reg. No./Substance:
530-78-9/Flufenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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