Document Detail


Penetration of digoxin into cerebrospinal fluid.
MedLine Citation:
PMID:  1012999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.
Authors:
G D Schott; D W Holt; A M Hayler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  52     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  700-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood-Brain Barrier
Digoxin / blood,  cerebrospinal fluid*
Female
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
20830-75-5/Digoxin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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