| Pendrin as a regulator of ECF and blood pressure. | |
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MedLine Citation:
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PMID: 19474731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Abnormal renal sodium handling plays a pivotal role in the pathophysiology of arterial hypertension. Though sodium is present in the diet as a chloride salt, most studies have focused on the renal mechanisms of sodium transport and their regulation, and very few have investigated the impact of chloride. However, strong evidence indicates that chloride may play a very important role in the 'prohypertensive' effects of sodium. RECENT FINDINGS: Several observations indicate that sodium has to be administered as NaCl and not as NaHCO3 to raise arterial blood pressure. Recently, genetic studies have pointed out the critical role of the most distal parts of the nephron in regulating sodium balance and blood pressure. Interestingly, in those segments, the transport of Na+ and Cl- proceeds separately, through different molecules. Recent evidence has demonstrated that an apical Cl-/HCO3- exchanger called pendrin is an absolute requirement for chloride reabsorption in the collecting system, indicating that chloride absorption is not passive and paracellular but is mediated by the intercalated cells. Importantly, pendrin disruption protects mice against mineralocorticoid-induced hypertension and impairs renal adaptation to a low NaCl diet. Moreover, recent findings suggest several mechanisms by which chloride transport might affect NaCl balance and blood pressure. SUMMARY: Pendrin-mediated chloride transport through intercalated cells appears to be an independent and important determinant of renal NaCl handling and therefore might represent a new target for blood pressure control. |
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Authors:
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Dominique Eladari; Régine Chambrey; Sebastian Frische; Marion Vallet; Aurélie Edwards |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 18 ISSN: 1535-3842 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 356-62 Citation Subset: IM |
Affiliation:
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Centre de recherche des Cordeliers, INSERM U 872 (equipe 3), ERL CNRS 7226, Paris, France. dominique.eladari@crc.jussieu.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Chloride-Bicarbonate Antiporters / physiology Chlorides / metabolism* Extracellular Fluid / metabolism* Humans Ion Transport Kidney / metabolism Kidney Tubules, Distal / metabolism Membrane Transport Proteins / physiology* Nephrons / metabolism Sodium Chloride / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK-53775/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chloride-Bicarbonate Antiporters; 0/Chlorides; 0/Membrane Transport Proteins; 0/SLC26A4 protein, human; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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