| Pendred syndrome and iodide transport in the thyroid. | |
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MedLine Citation:
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PMID: 18692402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pendred syndrome is an autosomal recessive disorder characterized by sensorineural hearing impairment, presence of goiter, and a partial defect in iodide organification, which may be associated with insufficient thyroid hormone synthesis. Goiter development and development of hypothyroidism are variable and depend on nutritional iodide intake. Pendred syndrome is caused by biallelic mutations in the SLC26A4 gene, which encodes pendrin, a transporter of chloride, bicarbonate and iodide. This review discusses the controversies surrounding the potential role of pendrin in mediating apical iodide efflux into the lumen of thyroid follicles, and discusses its functional role in the kidney and the inner ear. |
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Authors:
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Peter Kopp; Liuska Pesce; Juan Carlos Solis-S |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-08-07 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 19 ISSN: 1043-2760 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 260-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA. p-kopp@northwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Goiter
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genetics*,
metabolism* Hearing Loss, Sensorineural / genetics, metabolism Humans Iodides / metabolism* Membrane Transport Proteins / genetics*, metabolism* Syndrome Thyroid Gland / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1R01 DK63024-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Iodides; 0/Membrane Transport Proteins; 0/SLC26A4 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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