Document Detail

Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels.
MedLine Citation:
PMID:  23344819     Owner:  NLM     Status:  MEDLINE    
A unique technique for the rapid fabrication of thermoplastic microfluidic chips is described. The method enables the realization of fully-sealed microchannels in around one hour while requiring only minimal infrastructure by taking advantage of a solvent swelling mechanism that allows raised features to be patterned on the surface of homogeneous thermoplastic materials. Patterning is achieved without photolithography by simply drawing the desired microchannel pattern onto the polymer surface using a suitable ink as a masking layer, either manually or under robotic control, followed by timed exposure to solvent vapor to yield a desired depth for the masked channel features. The channels are then permanently sealed through solvent bonding of the microchannel chip to a mating thermoplastic substrate. The process is demonstrated using cyclic olefin copolymer as a thermoplastic material, with fully operational microfluidic devices fabricated following a true desktop manufacturing model suitable for rapid prototyping.
Omid Rahmanian; Don L DeVoe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lab on a chip     Volume:  13     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-27     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1102-8     Citation Subset:  IM    
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MeSH Terms
Microfluidic Analytical Techniques / instrumentation,  methods*
Polymers / chemistry
Solvents / chemistry
Grant Support
Reg. No./Substance:
0/Polymers; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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