Document Detail

Pen microfluidics: rapid desktop manufacturing of sealed thermoplastic microchannels.
MedLine Citation:
PMID:  23344819     Owner:  NLM     Status:  MEDLINE    
A unique technique for the rapid fabrication of thermoplastic microfluidic chips is described. The method enables the realization of fully-sealed microchannels in around one hour while requiring only minimal infrastructure by taking advantage of a solvent swelling mechanism that allows raised features to be patterned on the surface of homogeneous thermoplastic materials. Patterning is achieved without photolithography by simply drawing the desired microchannel pattern onto the polymer surface using a suitable ink as a masking layer, either manually or under robotic control, followed by timed exposure to solvent vapor to yield a desired depth for the masked channel features. The channels are then permanently sealed through solvent bonding of the microchannel chip to a mating thermoplastic substrate. The process is demonstrated using cyclic olefin copolymer as a thermoplastic material, with fully operational microfluidic devices fabricated following a true desktop manufacturing model suitable for rapid prototyping.
Omid Rahmanian; Don L DeVoe
Related Documents :
16311169 - Water resistance and extended wear sunscreens.
22278779 - Advances in polymeric systems for tissue engineering and biomedical applications.
16938999 - Results from an autonomous underwater vehicle towed hydrophone array experiment in nant...
10053209 - Transdermal delivery of naloxone: ex vivo permeation studies.
17927949 - Stratum corneum hydration: phase transformations and mobility in stratum corneum, extra...
25494039 - Functionalized silicon nanoparticles from reactive cavitation erosion of silicon wafers.
19367859 - Coarse-grained simulations of rapid assembly kinetics for polystyrene-b-poly(ethylene o...
24268059 - Valuing flexibilities in the design of urban water management systems.
17518489 - Comparison of electron injection dynamics from re-bipyridyl complexes to tio2 nanocryst...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lab on a chip     Volume:  13     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-27     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1102-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Microfluidic Analytical Techniques / instrumentation,  methods*
Polymers / chemistry
Solvents / chemistry
Grant Support
Reg. No./Substance:
0/Polymers; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Malariotherapy at Mont Park: the earliest surviving movie of psychiatric treatment in Australia.
Next Document:  Biochemical modulation of cell energy by 2-deoxyglucose and malonate in 7,12-dimethylbenz(a)anthrace...