Document Detail

Pemphigus vegetans-Neumann variant associated with intranasal heroin abuse.
MedLine Citation:
PMID:  9810919     Owner:  NLM     Status:  MEDLINE    
Pemphigus vegetans is variant of pemphigus vulgaris accounting for 5% of all patients with pemphigus disorders. We describe a case of pemphigus vegetans-Neumann type associated with intranasal heroin abuse, restricted to the modified mucous membranes. The results of routine histology and direct and indirect immunofluorescence studies confirmed the diagnosis. The patient responded to oral prednisone of 40 mg daily for 1 month, followed by reduction to a maintenance dose of 15 mg daily. A complete remission was sustained for 6 months. The relationship between intranasal heroin use and the development of pemphigus vegetans remains uncertain but appears to be an intriguing possibility in this patient.
J B Downie; D P Dicostanzo; S R Cohen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  39     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-24     Completed Date:  1998-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  872-5     Citation Subset:  IM    
Department of Dermatology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York 10003, USA.
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MeSH Terms
Administration, Intranasal
Heroin / administration & dosage
Heroin Dependence / complications*
Keratosis / etiology,  pathology
Lip Diseases / etiology,  pathology
Mouth Diseases / etiology*,  pathology
Narcotics / administration & dosage
Nose Diseases / etiology*,  pathology
Pemphigus / etiology*,  pathology
Tongue Diseases / etiology,  pathology
Reg. No./Substance:
0/Narcotics; 561-27-3/Heroin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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